Amino-PEG4-alkyne

CAS 1013921-36-2C11H21NO4Chemical Synthesis

Amino-PEG4-alkyne (CAS: 1013921-36-2) is a heterobifunctional linker with the molecular formula C11H21NO4 and a molar mass of 231.29 g/mol. It features an amine terminus and a terminal alkyne, separated by a hydrophilic tetraethylene glycol (PEG4) spacer. This structure facilitates the conjugation of molecules containing carboxylic acids to those with azides, offering enhanced water solubility and reduced aggregation for modified biomolecules.

IUPAC: 3,6,9,12-Tetraoxapentadec-14-yn-1-amine,Acetylene-PEG4-amine,H2N-PEG4-propyne,Triethylene glycol 2-aminoethyl propargyl ether
Synonyms: 3,6,9,12-Tetraoxapentadec-14-yn-1-amineAcetylene-PEG4-amineH2N-PEG4-propyneTriethylene glycol 2-aminoethyl propargyl ether

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Amino-PEG4-alkyne (C11H21NO4) — chemical structure, CAS 1013921-36-2; Chemistry, fine chemical supplied by Tech Serve Solutions

Bifunctional LinkersChemical BiologyChemical SynthesisLinkers and Crosslinkers

01 /Applications

Bioconjugation via Click Chemistry

This reagent enables the efficient attachment of azide-containing molecules to carboxylic acid-bearing compounds. The amine group reacts with carboxylic acids using standard coupling reagents, while the terminal alkyne participates in copper-catalyzed 1,3-dipolar cycloaddition (click chemistry) with azides.

Biomolecule Modification

The hydrophilic PEG4 spacer enhances the water solubility of modified biomolecules such as antibodies, proteins, and peptides. This linker allows for the introduction of a terminal alkyne for subsequent functionalization or labelling of these biomolecules.

Protein Solubility and Stability Enhancement

Incorporating the PEG4 spacer into modified proteins can help reduce aggregation in aqueous solutions by increasing their hydrophilic character, thereby improving stability.

02 /Properties

Molecular weight	231.29
Empirical formula	C11H21NO4
Storage temperature	−20°C
Application	Heterobifunctional linker enabling the connection of an azide containing compound or biomolecule to one with a carboxylic acid. The amine group can be linked to a carboxylic acid through standard coupling procedures (EDC, product #39391, etc...) and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification of carboxylic acid containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

03 /Identifiers & registry

CAS number

1013921-36-2

MDL number

MFCD22380736

04 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

05 /Frequently asked questions

What is Amino-PEG4-alkyne used for?

Amino-PEG4-alkyne is a heterobifunctional linker used for conjugating molecules containing carboxylic acids to those with azides via click chemistry. It is particularly useful for modifying biomolecules like proteins and peptides, enhancing their water solubility and stability.

What is the CAS number and formula for Amino-PEG4-alkyne?

The CAS number for Amino-PEG4-alkyne is 1013921-36-2 and its empirical formula is C11H21NO4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this chemical for research and development purposes. The specific assay and purity information is available on the product's Certificate of Analysis. We do not represent this product as meeting USP, BP, EP, or other pharmacopoeial standards.

How should Amino-PEG4-alkyne be handled and stored?

Amino-PEG4-alkyne should be stored at -20°C. Refer to the Safety Data Sheet (SDS) for comprehensive handling precautions, hazard information, and appropriate personal protective equipment (PPE).

Is Amino-PEG4-alkyne a controlled substance?

Based on the provided data, Amino-PEG4-alkyne is not classified as a controlled substance.

How is Amino-PEG4-alkyne shipped?

Tech Serve Solutions exports fine chemicals globally. Shipping conditions are optimised to maintain product integrity during transit. Please contact us for specific shipping details or export inquiries.