Boc-Phe(4-I)-OH

CAS 62129-44-6(CH3)3COCONHCH(COOH)CH2C6H4IChemical Synthesis

Boc-Phe(4-I)-OH (CAS 62129-44-6) is a protected unnatural amino acid derivative, specifically N-tert-butoxycarbonyl-4-iodo-L-phenylalanine. With a molecular weight of 391.20 g/mol, this compound serves as a valuable building block in chemical synthesis and peptide chemistry. Its structure, featuring an iodinated phenylalanine side chain and a Boc protecting group, facilitates its incorporation into complex molecules and peptides for various research and development applications.

IUPAC: Boc-4-iodo-L-phenylalanine
Synonyms: Boc-4-iodo-L-phenylalanine

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Boc-Phe(4-I)-OH ((CH3)3COCONHCH(COOH)CH2C6H4I) — chemical structure, CAS 62129-44-6; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical BiologyChemical SynthesisPeptide ChemistryPhenylalanine Derivatives

01 /Applications

Peptide Synthesis

Boc-Phe(4-I)-OH is utilised as a specialised building block in solid-phase and solution-phase peptide synthesis. The 4-iodo substituent allows for further functionalisation via cross-coupling reactions, enabling the creation of modified peptides for biochemical research.

Chemical Biology Research

This compound is employed in chemical biology to introduce an iodinated phenylalanine residue into peptides or proteins. The iodine atom can serve as a handle for radiolabelling or for spectroscopic studies.

Organic Synthesis Intermediate

As a derivative of phenylalanine, Boc-Phe(4-I)-OH functions as a versatile intermediate in complex organic synthesis. Its protected amino and carboxyl groups, along with the reactive iodo-substituent, make it suitable for various synthetic transformations.

Unnatural Amino Acid Chemistry

The compound is a key reagent for researchers exploring the incorporation and effects of unnatural amino acids in biological systems or synthetic materials. It enables the study of structure-activity relationships in modified biomolecules.

02 /Properties

Molecular weight	391.20
Linear formula	(CH3)3COCONHCH(COOH)CH2C6H4I
Assay	≥99.0% (TLC)
Optical activity	[α]20/D +22.5±3°, c = 1% in ethyl acetate
Melting point	~150 °C (dec.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

62129-44-6

MDL number

MFCD00037119

Beilstein registry

4503851

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Boc-Phe(4-I)-OH used for?

Boc-Phe(4-I)-OH is primarily used as a building block in peptide synthesis, chemical biology research, organic synthesis, and unnatural amino acid chemistry.

What is the CAS number and formula for Boc-Phe(4-I)-OH?

The CAS number is 62129-44-6, and its linear formula is (CH3)3COCONHCH(COOH)CH2C6H4I.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Boc-Phe(4-I)-OH with an assay of ≥99.0% (TLC). TSS does not represent this product as USP, BP, or EP grade.

What are the safety considerations for handling Boc-Phe(4-I)-OH?

Handling Boc-Phe(4-I)-OH requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The substance has a WGK Germany rating of 3, indicating it is hazardous to water.