Boc-D-Phe(2-CF3)-OH
Boc-D-Phe(2-CF3)-OH (CAS: 346694-78-8) is a trifluoromethylated phenylalanine derivative with the molecular formula C15H18F3NO4 and a molecular weight of 333.30 g/mol. This unnatural amino acid derivative is a valuable building block in chemical synthesis, particularly within peptide chemistry and chemical biology research. Its unique structure allows for the introduction of specific steric and electronic properties into peptides and other complex molecules.
- IUPAC
- Boc-2-(trifluoromethyl)-D-phenylalanine
- Synonyms
- Boc-2-(trifluoromethyl)-D-phenylalanine

Peptide Synthesis
Used as a modified amino acid building block in solid-phase or solution-phase peptide synthesis to create peptides with altered conformational stability, binding affinity, or metabolic resistance.
Chemical Biology Research
Incorporated into biomolecules or probes to study protein-ligand interactions, enzyme mechanisms, or to develop novel biologically active compounds.
Medicinal Chemistry
Employed in the design and synthesis of novel drug candidates, where the trifluoromethyl group can enhance lipophilicity, metabolic stability, and binding interactions.
Asymmetric Synthesis
Serves as a chiral precursor or intermediate in the synthesis of complex organic molecules and other unnatural amino acids.
| Molecular weight | 333.30 |
|---|---|
| Empirical formula | C15H18F3NO4 |
| Assay | ≥98.0% (TLC) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Boc-D-Phe(2-CF3)-OH used for?
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Boc-D-Phe(2-CF3)-OH is primarily used as a building block in peptide synthesis, chemical biology research, medicinal chemistry, and asymmetric synthesis due to its unique trifluoromethylated phenylalanine structure.
What is the CAS number and molecular formula for Boc-D-Phe(2-CF3)-OH?
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The CAS number is 346694-78-8 and the molecular formula is C15H18F3NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Boc-D-Phe(2-CF3)-OH with a minimum assay of ≥98.0% (determined by TLC). This product is typically supplied for research and development purposes and is not represented as USP, BP, or EP grade.
How should Boc-D-Phe(2-CF3)-OH be handled safely?
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When handling Boc-D-Phe(2-CF3)-OH, it is essential to wear appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used if there is a risk of airborne exposure. Consult the Safety Data Sheet (SDS) for detailed handling and safety information. The WGK classification is 3.
Is Boc-D-Phe(2-CF3)-OH a controlled substance?
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Based on the provided data, Boc-D-Phe(2-CF3)-OH is not indicated as a controlled substance.
How is this chemical packed and shipped?
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Tech Serve Solutions, as a global supplier and exporter, ensures that chemicals like Boc-D-Phe(2-CF3)-OH are packed and shipped in compliance with international regulations for hazardous materials, suitable for export worldwide.
How can I request a sample or quote for Boc-D-Phe(2-CF3)-OH?
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To request a sample or a quotation for Boc-D-Phe(2-CF3)-OH, please contact our sales department through the inquiry form on our website or via direct email, providing your contact details and the quantity required.
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