Bis(3,5-di(trifluoromethyl)phenyl)phosphine
Bis(3,5-di(trifluoromethyl)phenyl)phosphine (CAS 166172-69-6, C16H7F12P, molar mass 458.18 g/mol) is an electron-poor secondary diarylphosphine bearing two 3,5-bis(trifluoromethyl)phenyl groups and a reactive P-H bond. Supplied as a low-melting solid (m.p. 69-73 degC), it serves chiefly as a building block and ligand precursor in organophosphorus and coordination chemistry. Tech Serve Solutions supplies it as a research-grade reagent to synthesis and catalysis laboratories worldwide.
- Synonyms
- Bis(3,5-di(trifluoromethyl)phenyl)phosphineBis[3,5-bis(trifluoromethyl)phenyl]phosphineBis(3,5-bis(trifluoromethyl)phenyl)phosphineDi(3,5-bis(trifluoromethyl)phenyl)phosphineCAS 166172-69-6C16H7F12PMFCD01630858
Phosphine ligand precursor
The reactive P-H bond allows elaboration into tertiary phosphines and bidentate ligands. The strongly electron-withdrawing bis(trifluoromethyl)aryl groups give access to electron-poor phosphorus donors used in coordination chemistry.
Organophosphorus synthesis
Used as a building block in chemical synthesis, where the secondary phosphine participates in P-C and P-H bond-forming reactions such as hydrophosphination and metallation to construct more complex phosphorus frameworks.
Catalysis and inorganic chemistry research
Of interest in catalysis and inorganic chemistry programmes that exploit fluorinated, electron-deficient phosphines for tuning the electronic environment at a metal centre.
Fluorinated phosphorus precursor
Acts as a phosphorus precursor that introduces two 3,5-bis(trifluoromethyl)phenyl substituents, a common motif for adjusting solubility, lipophilicity and steric and electronic properties in organometallic and materials research.
| Molecular weight | 458.18 |
|---|---|
| Empirical formula | C16H7F12P |
| Melting point | 69-73 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 3335 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bis(3,5-di(trifluoromethyl)phenyl)phosphine used for?
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It is used mainly as a secondary diarylphosphine building block and ligand precursor in organophosphorus and coordination chemistry. Its reactive P-H bond and electron-poor fluorinated aryl groups make it valuable for preparing tertiary phosphines and electron-deficient phosphorus ligands for catalysis and inorganic chemistry research.
What is the CAS number and molecular formula of Bis(3,5-di(trifluoromethyl)phenyl)phosphine?
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Its CAS number is 166172-69-6 and its empirical formula is C16H7F12P (Hill notation), corresponding to a molecular weight of 458.18 g/mol. The MDL number is MFCD01630858 and the reported melting point is 69-73 degC.
What grade and purity does Tech Serve Solutions supply?
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We supply Bis(3,5-di(trifluoromethyl)phenyl)phosphine as a research-grade reagent for synthesis and catalysis use. We do not represent it as USP, BP or EP pharmacopoeial grade. Current assay and a batch certificate of analysis are provided on request so you can confirm specifications before purchase.
What are the safety and handling precautions for this phosphine?
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It is classified under GHS07 with the signal word Warning and carries hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation) and H335 (may cause respiratory irritation). Handle with gloves, eye protection and an N95-type dust mask, avoid dust generation, and work with adequate ventilation. As a fluorinated phosphine it is also assigned water hazard class WGK 3 (highly hazardous to water), so prevent release to drains and the environment. Always consult the SDS before use.
How is Bis(3,5-di(trifluoromethyl)phenyl)phosphine packed, shipped and exported?
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It is packed in sealed, appropriately labelled containers sized to the order, from gram research quantities to larger volumes. For transport it is assigned UN 3335, so it ships as dangerous goods under applicable air, sea and road regulations with full documentation. We export worldwide from India with the required compliance and shipping paperwork.
How do I request a sample or quote?
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Contact Tech Serve Solutions with your required quantity, packaging and destination, and our team will respond with availability, lead time and a formal quotation. Samples and a current certificate of analysis can be arranged for evaluation.
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