Bis(3,5-dimethyl-4-methoxyphenyl)chlorophosphine
Bis(3,5-dimethyl-4-methoxyphenyl)chlorophosphine (CAS 136802-85-2) is an air-sensitive organophosphorus reagent with the molecular formula C18H22ClO2P and a molar mass of 336.79 g/mol. The reactive P-Cl bond makes it a versatile building block in chiral phosphine and phosphine-phosphite ligand synthesis for asymmetric catalysis. Tech Serve Solutions supplies it as a research-grade reagent at 95% assay for laboratory and process-development use worldwide.
- Synonyms
- Bis(3,5-dimethyl-4-methoxyphenyl)chlorophosphineChlorobis(3,5-dimethyl-4-methoxyphenyl)phosphineBis(4-methoxy-3,5-dimethylphenyl)chlorophosphineC18H22ClO2PCAS 136802-85-2
Chiral phosphine-phosphite ligand synthesis
Used as a phosphorus precursor in the preparation of TADDOL-derived chiral phosphine-phosphite ligands. Such ligands are applied in asymmetric hydroformylation and related enantioselective transformations.
Ferrocene-based diphosphine preparation
Serves as a reactant in the synthesis of ferrocene-based chiral diphosphines. These structurally defined ligands support asymmetric hydrogenation of BIFEP-type biferrocenes and similar substrates.
Asymmetric electrophilic phosphination
The electrophilic P-Cl centre makes the compound a reactant for asymmetric organocatalytic electrophilic phosphination, introducing the diarylphosphino group into target molecules under chiral catalysis.
Phosphane-borane chemistry
Employed in routes involving the alcoholysis of phosphane-boranes, where it functions as a defined aryl-substituted phosphorus building block for protected phosphine intermediates.
Research and process development
Supplied as a research-grade reagent for organometallic and catalysis laboratories developing new ligand frameworks. It is intended for synthetic and process-development work rather than finished-product formulation.
| Molecular weight | 336.79 |
|---|---|
| Empirical formula | C18H22ClO2P |
| Assay | 95% |
| Density | 1.141 g/cm3 at 25 °C |
| Refractive index | n20/D 1.597 |
| Application | Reactant for:• Asymmetric organocatalytic electrophilic phosphination1• Asymmetric hydroformulation using Taddol-based chiral phosphine-phosphite ligands2• Synthesis of ferrocene-based chiral diphosphines3• Alcoholysis of phosphane-boranes4• Asymmetric hydrogenations of bifep-type biferrocenes5 |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Flash point | >110 °C / >230 °F |
| Transport (UN / ADR) | UN 1760 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-43-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Bis(3,5-dimethyl-4-methoxyphenyl)chlorophosphine used for?
+
It is a chlorophosphine reagent used mainly as a phosphorus building block in chiral ligand synthesis. Documented uses include preparing TADDOL-based phosphine-phosphite ligands, ferrocene-based chiral diphosphines, asymmetric electrophilic phosphination, and phosphane-borane chemistry for asymmetric catalysis.
What is the CAS number and molecular formula of Bis(3,5-dimethyl-4-methoxyphenyl)chlorophosphine?
+
Its CAS number is 136802-85-2 and its molecular formula is C18H22ClO2P (Hill notation), with a molecular weight of 336.79 g/mol. Typical physical data include a refractive index of n20/D 1.597 and a density of 1.141 g/cm3 at 25 C.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this compound as a research-grade reagent with a typical assay of 95%. It is offered for laboratory and process-development use; we do not represent it as USP, BP or EP pharmacopoeial grade.
What are the safety and handling requirements for this chlorophosphine?
+
It is classified GHS05 with the signal word Danger and hazard statement H314 (causes severe skin burns and eye damage). It is also moisture-sensitive and reacts with water. Handle under inert, dry conditions with eye and face protection, gloves and suitable respiratory protection, and consult the SDS before use.
How is Bis(3,5-dimethyl-4-methoxyphenyl)chlorophosphine packed, shipped and exported?
+
It is supplied in sealed, moisture-protected containers sized to the order and is classified for transport as UN 1760, Class 8, Packing Group III (corrosive liquid). Tech Serve Solutions manages compliant export documentation and dangerous-goods handling for international shipments.
How do I request a sample or quote?
+
Contact Tech Serve Solutions with your required quantity, packaging and destination, and our team will confirm availability, lead time and export terms. Sample and bulk enquiries are both welcome.
▶ Related products
Benzeneruthenium(II) chloride dimer
Ru2(C6H6)2Cl4
Catalysis & Inorganic
Benzoylferrocene
C17H14FeO
Catalysis & Inorganic
Benzyldiphenylphosphine
C6H5CH2P(C6H5)2
Catalysis & Inorganic
Beryllium
Be
Catalysis & Inorganic
Beryllium oxide
BeO
Catalysis & Inorganic![Bicyclo[2.2.1]hepta-2,5-diene-rhodium(I) chloride dimer — chemical structure, CAS 12257-42-0; Catalysis & Inorganic, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F12257-42-0.png&w=3840&q=75)
Bicyclo[2.2.1]hepta-2,5-diene-rhodium(I) chloride dimer
Catalysis & Inorganic
![Bis[(10,11-η)-5-[(11bS)-dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl- κP4]-5H-dibenz[b,f]azepine]rhodium(I) tetrafluorobo — chemical structure, CAS 1228149-03-8; Catalysis & Inorganic, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F1228149-03-8.png&w=3840&q=75)
Bis[(10,11-η)-5-[(11bS)-dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl- κP4]-5H-dibenz[b,f]azepine]rhodium(I) tetrafluorobo
1-d:1′
Catalysis & Inorganic![Bis[(2-dimethylamino)phenyl]amine nickel(II) chloride (C16H20ClN3Ni) — chemical structure, CAS 1033772-47-2; Catalysis & Inorganic, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F1033772-47-2.png&w=3840&q=75)
Bis[(2-dimethylamino)phenyl]amine nickel(II) chloride
C16H20ClN3Ni
Catalysis & Inorganic▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis