Acridine Mutagen ICR 191
Acridine Mutagen ICR 191 (CAS: 17070-45-0), with the empirical formula C19H21Cl2N3O · 2HCl and a molecular weight of 451.22 g/mol, is a potent frameshift mutagen. This acridine derivative is primarily recognised for its utility as a standard in mutagenicity testing, specifically the Ames test, employing Salmonella and E. coli strains. Its fluorescent properties also lend it to applications in biological staining.
- IUPAC
- 6-Chloro-9-[3-(2-chloroethylamino)propylamino]-2-methoxyacridine dihydrochloride
Mutagenicity Testing Standard
ICR 191 serves as a validated frameshift mutagenic standard for the Ames test, crucial for assessing the mutagenic potential of chemical compounds in bacterial systems like Salmonella and E. coli.
Nucleic Acid Stain
As a fluorescent acridine derivative, it can intercalate into DNA, enabling its use as a stain for visualising nucleic acids in biological research.
Biochemical Research Reagent
Its specific mutagenic properties make it a valuable tool for researchers studying DNA-mutation mechanisms and repair pathways.
| Molecular weight | 451.22 |
|---|---|
| Empirical formula | C19H21Cl2N3O · 2HCl |
| Solubility | DMSO: soluble |
| Storage temperature | 2-8°C |
| Suitability | suitable for Ames test in Salmonella and E. coli (Frameshift mutagenic standard) |
Hazard statements
- H300Fatal if swallowed
- H310Fatal in contact with skin
- H330Fatal if inhaled
- H350May cause cancer
Precautionary statements
- P201Obtain special instructions before use
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P302IF ON SKIN
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGI |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 45-46-26/27/28 |
| Safety statements (S) | 53-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Acridine Mutagen ICR 191 used for?
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Acridine Mutagen ICR 191 (CAS: 17070-45-0) is primarily used as a standard for frameshift mutagenicity testing, particularly in the Ames test with Salmonella and E. coli, and as a fluorescent stain for nucleic acids.
What is the CAS number and chemical formula for Acridine Mutagen ICR 191?
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The CAS number is 17070-45-0, and the empirical formula is C19H21Cl2N3O · 2HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Acridine Mutagen ICR 191 suitable for Ames test applications. As this is a specialised research chemical, TSS does not represent it as USP, BP, or EP grade.
How should Acridine Mutagen ICR 191 be handled and stored?
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Handle with extreme care due to its severe toxicity (H300, H310, H330) and potential carcinogenicity (H350). Wear appropriate personal protective equipment, including eyeshields, gloves, and a full-face particle respirator. Store at 2-8°C.
Is Acridine Mutagen ICR 191 a controlled substance?
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The provided data does not indicate that Acridine Mutagen ICR 191 is a controlled substance. However, users should always verify local regulations.
How is Acridine Mutagen ICR 191 packed and shipped?
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Acridine Mutagen ICR 191 is packed and shipped according to UN 2811 (Toxic solid, organic, n.o.s.) regulations (Class 6.1, PG I), ensuring safe transit globally. Please consult our shipping department for specific export details.
How can I request a quote or sample for Acridine Mutagen ICR 191?
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To request a quote or a sample of Acridine Mutagen ICR 191, please contact our sales team through the website or via email, specifying your inquiry and location.
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