Acriflavine
Acriflavine (CAS: 8048-52-0; Formula: C14H14ClN3; Molar Mass: 259.73 g/mol) is a fluorescent dye and acridine derivative supplied by TSS. This compound is primarily utilised for its fluorescent properties, particularly for labeling high molecular weight RNA molecules in biological research. It is also employed in fluorescence steady-state measurements and can function as a pH sensor.
- IUPAC
- 3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-diaminoacridine (proflavine),Euflavine,Trypaflavine Neutral
- Synonyms
- EuflavineProflavine hemisulfate saltTrypaflavine Neutral3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-diaminoacridine
Fluorescent Labeling of RNA
Acriflavine serves as a fluorescent probe for labeling high molecular weight RNA molecules. Its excitation and emission wavelengths vary depending on the solvent, enabling its use in diverse experimental conditions.
Fluorescence Steady-State Measurements
This compound is utilized in fluorescence steady-state measurements as a donor molecule. When paired with an acceptor like rhodamine 6G, it can function as a pH sensor.
Biological Staining
As a fluorescent stain, Acriflavine is valuable in various biological and histological applications, including cell biology and hematology, for visualizing cellular structures.
| Molecular weight | 259.73 |
|---|---|
| Empirical formula | C14H14ClN3 |
| Assay | ≥95.0% (AT) |
| Solubility | H2O: soluble0.33 g/mL (lit.)(lit.) |
| Application | Acriflanvine is used for fluorescently labeling of high molecular weight RNA molecules 1.Excitation and emission wavelengths in various solvents 2:• Methanol: λex = 424 nm; λem = 518 nm• Ethanol: λex = 426 nm; λem = 524 nm• Propanol: λex = 430 nm; λem = 512 nm• Butanol: λex = 430 nm; λem = 526 nm• Formamide: λex = 434 nm; λem = 524 nm• Glycerol: λex = 432 nm; λem = 540 nm• Water: λex = 416 nm; λem = 514 nmInsoluble in ether, chloroform, and fixed oils. Utilized in fluorescence steady state measurements as a donor molecule (when paired with rhodamine 6G as the acceptor) to function as a pH sensor 3. |
| Suitability | suitable for fluorescence |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Transport (UN / ADR) | UN 3077 9 / PGIII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 22-36/37/38-50 |
| Safety statements (S) | 26-36/37/39-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Fluorescence | λex 463 nm; λem 490 nm in ethanol |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Acriflavine used for?
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Acriflavine is used for fluorescently labeling high molecular weight RNA molecules, in fluorescence steady state measurements as a donor molecule, and as a pH sensor when paired with suitable acceptors.
What are the CAS number and formula for Acriflavine?
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The CAS number for Acriflavine is 8048-52-0, and its empirical formula is C14H14ClN3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Acriflavine with an assay of ≥95.0% (AT). We do not represent this product as USP, BP, or EP grade.
What are the safety considerations when handling Acriflavine?
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Acriflavine is a Warning substance. It is harmful if swallowed (H302), causes skin irritation (H315), causes serious eye irritation (H319), and may cause respiratory irritation (H335). Always handle with appropriate personal protective equipment and follow safety guidelines.
Is Acriflavine a controlled substance?
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The provided data does not indicate that Acriflavine is a controlled substance.
How is Acriflavine packed, shipped, and exported?
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Acriflavine is packed and shipped according to international regulations, including UN 3077 9 / PGIII for transportation. Tech Serve Solutions exports globally.
How can I request a sample or quote for Acriflavine?
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Please contact Tech Serve Solutions directly through our website or sales department to request a sample or obtain a quote for Acriflavine.
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