7-Hydroxycoumarin-3-carboxylic acid
7-Hydroxycoumarin-3-carboxylic acid (CAS: 779-27-1), with the empirical formula C10H6O5 and a molecular weight of 206.15, is a valuable chemical compound. It serves as a key fluorogenic substrate in glycosyltransferase assays and functions as a non-cinnamate-class substrate analog for studying 4-hydroxycinnamate decarboxylase activity. This compound is recognized for its suitability in fluorescence applications.
- IUPAC
- Umbelliferone-3-carboxylic acid
Fluorogenic Substrate for Glycosyltransferase Assays
7-Hydroxycoumarin-3-carboxylic acid is employed as a fluorogenic substrate, enabling the detection and quantification of glycosyltransferase activity. Its fluorescent properties allow for sensitive monitoring of enzymatic reactions in biochemical research.
Substrate Analog for Enzyme Studies
This compound acts as a useful analog for studying enzymes such as 4-hydroxycinnamate decarboxylase (4-HCD). It can be used to investigate enzyme-inducing activities in biological systems, offering insights into metabolic pathways.
Fluorescence Spectroscopy Reagent
With distinct excitation and emission wavelengths, 7-Hydroxycoumarin-3-carboxylic acid is suitable for fluorescence spectroscopy. It can be used in various buffer conditions, demonstrating different spectral characteristics.
| Molecular weight | 206.15 |
|---|---|
| Empirical formula | C10H6O5 |
| Assay | ≥98.0% (TLC) |
| Solubility | DMF: solubleDMSO: solublealcohols: soluble |
| Application | 7-Hydroxycoumarin-3-carboxylic acid (7-OHCCA) is used as a fluorogenic substrate for glycosyltransferase assays. 7-OHCCA may be used as a non-cinnamate-class substrate analog to study 4-hydroxycinnamate decarboxylase (4-HCD)-inducing activity in Klebsiella oxytoca cells. |
| Suitability | suitable for fluorescence |
| Melting point | 261 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Pka  | 7.04 |
|---|---|
| Fluorescence | λex 342 nm; λem 447 nm (pH 4.0)λex 386 nm; λem 448 nm in 0.1 M Tris pH 9.0 |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 7-Hydroxycoumarin-3-carboxylic acid used for?
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7-Hydroxycoumarin-3-carboxylic acid is primarily used as a fluorogenic substrate for glycosyltransferase assays and as a substrate analog for studying 4-hydroxycinnamate decarboxylase (4-HCD) activity. It is also suitable for fluorescence applications.
What are the CAS number and formula for 7-Hydroxycoumarin-3-carboxylic acid?
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The CAS number is 779-27-1, and the empirical formula is C10H6O5.
What grade and purity does Tech Serve Solutions supply for 7-Hydroxycoumarin-3-carboxylic acid?
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Tech Serve Solutions supplies 7-Hydroxycoumarin-3-carboxylic acid with a purity of ≥98.0% (TLC). This product is intended for research and laboratory use and is not represented as USP, BP, or EP grade.
How should 7-Hydroxycoumarin-3-carboxylic acid be handled safely?
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7-Hydroxycoumarin-3-carboxylic acid is classified with warning signal word and hazards including skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Ensure good ventilation when handling.
Is 7-Hydroxycoumarin-3-carboxylic acid available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 7-Hydroxycoumarin-3-carboxylic acid.
How can I request a sample or quote for 7-Hydroxycoumarin-3-carboxylic acid?
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Please contact our customer service team via our website or telephone to request a sample or a quote for 7-Hydroxycoumarin-3-carboxylic acid.
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