6-(p-Toluidino)-2-naphthalenesulfonyl chloride
6-(p-Toluidino)-2-naphthalenesulfonyl chloride (CAS: 62778-24-9) is a fluorescent, hydrophobic probe with a molecular weight of 331.82 g/mol. It is primarily used for labeling peptides to facilitate the monitoring of conformational changes in molecular assemblies. This is achieved by measuring alterations in fluorescence intensity upon such changes, making it a valuable tool in biochemical and biophysical research.
- IUPAC
- 2,6-TNS-Cl,6-(4-Methylanilino)naphthalene-2-sulfonylchloride,6-[(4-methylphenyl)amino]-2-naphthalenesulfonylchloride
- Synonyms
- 2,6-TNS-Cl6-[(4-methylphenyl)amino]-2-naphthalenesulfonyl chloride
Peptide Labeling for Conformational Studies
This compound serves as a fluorescent label for peptides. It enables researchers to detect and quantify conformational changes within molecular assemblies by observing shifts in fluorescence intensity.
Biochemical and Biophysical Research
Its fluorescent properties and hydrophobic nature make it suitable for a range of applications in biochemical and biophysical investigations, particularly those involving membrane-associated processes or protein interactions.
Fluorescent Probe Development
As a functionalized naphthalenesulfonyl chloride, it can be used as a building block in the synthesis of more complex fluorescent probes and indicators for biological research.
| Molecular weight | 331.82 |
|---|---|
| Empirical formula | C17H14ClNO2S |
| Assay | ≥98.0% (HPLC) |
| Solubility | DMF: solubleacetonitrile: soluble |
| Storage temperature | 2-8°C |
| Application | 6-(p-Toluidino)-2-naphthalenesulfonyl chloride is a fluorescent, hydrophobic probe utilized for labeling peptides to monitor conformational changes of a molecular assembly by measuring alterations in fluorescence intensity 1. |
| Suitability | suitable for fluorescence |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Fluorescence | λex 381 nm in methanol |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-(p-Toluidino)-2-naphthalenesulfonyl chloride used for?
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It is used for labeling peptides to monitor conformational changes of molecular assemblies by measuring alterations in fluorescence intensity. It is also applicable in biochemical and biophysical research and as a component in fluorescent probe development.
What is the CAS number and formula for 6-(p-Toluidino)-2-naphthalenesulfonyl chloride?
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The CAS number is 62778-24-9. The empirical formula (Hill notation) is C17H14ClNO2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of ≥98.0% (HPLC). It is suitable for fluorescence applications. We do not represent it as USP, BP, EP, or any other pharmacopoeia grade.
How should 6-(p-Toluidino)-2-naphthalenesulfonyl chloride be handled safely?
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This compound is a Warning substance (GHS07) with hazards H315, H319, and H335. Appropriate personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Handle in a well-ventilated area, avoid dust formation, and prevent contact with skin, eyes, and clothing.
Is this product packed, shipped, or exported globally by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents.
How can I request a sample or quote for this chemical?
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Please contact our sales department via our website or by telephone to request a sample or a quotation for 6-(p-Toluidino)-2-naphthalenesulfonyl chloride.
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