6-Aminofluorescein
6-Aminofluorescein (CAS: 51649-83-3, C20H13NO5) is a fluorescent labeling reagent with a molecular weight of 347.32 g/mol. This compound serves as a valuable tool in biochemical research, primarily for fluorescent labelling applications. Its ability to attach to specific molecules allows for detection and quantification in various biological and chemical assays, including the characterisation of nanostructures and the detection of oxidative damage.
- IUPAC
- Fluoresceinamine isomer II
Fluorescent Labelling Reagent
6-Aminofluorescein is employed as a fluorescent labelling reagent for the characterisation of fullerene-based liposome nanostructures, known as 'buckysomes'. It facilitates the visualisation and quantification of these complex structures.
Detection of Oxidative Damage
This compound, particularly in its decarboxylated form, can be used to detect aldehyde groups that result from oxidative damage to proteins. This application is valuable in biochemical studies investigating cellular stress and damage.
Chromatography Derivatization
As a derivatization agent, 6-Aminofluorescein can be used in conjunction with chromatography techniques. It aids in the detection and analysis of specific analytes by introducing a fluorescent tag.
| Molecular weight | 347.32 |
|---|---|
| Empirical formula | C20H13NO5 |
| Application | 6-Aminofluorescein has been demonstrated to be useful fluorescent labeling reagent for fullerene-based liposome nanostructures termed ‘buckysomes’1. 6-aminofluorescein dissolved in 0.1 N NaOH can be quantified from a maximum absorbance at 490 nm. Decarboxylated 6-aminofluorescein dissolved 6 N HCl (prepare by constant boiling at 110° C for 24 h) can be quantified from a maximum absorbance at 454 nm. Aldehyde groups are formed by oxidateive damage to proteins, which can be detected by conjugation to decarboxylated 6-aminofluorescein2. |
| Melting point | 285 °C (dec.)(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Product Line | BioReagent |
|---|---|
| Absorption | λmax 495 nm |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Aminofluorescein used for?
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6-Aminofluorescein is primarily used as a fluorescent labelling reagent for nanostructures and for detecting aldehyde groups indicative of oxidative damage in proteins. It is also used as a derivatization agent in chromatography.
What is the CAS number and molecular formula for 6-Aminofluorescein?
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The CAS number for 6-Aminofluorescein is 51649-83-3, and its molecular formula is C20H13NO5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 6-Aminofluorescein typically as a research or technical grade chemical. The specific assay and purity are detailed in the product specifications. We do not represent this product as USP, BP, or EP grade unless explicitly stated.
What are the main safety concerns when handling 6-Aminofluorescein?
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6-Aminofluorescein is classified with GHS07 (Warning) and carries hazard statements H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used.
How is 6-Aminofluorescein packed, shipped, and exported?
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Tech Serve Solutions packages and ships 6-Aminofluorescein in accordance with all relevant national and international regulations for chemical transport. We are experienced global exporters.
How can I request a sample or quote for 6-Aminofluorescein?
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To request a sample or a quotation for 6-Aminofluorescein, please contact our sales team directly via our website or provide your details through the product inquiry form.
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