Glybenclamide

CAS 10238-21-8C23H28ClN3O5SCell Biology

Glybenclamide (CAS: 10238-21-8), a sulfonylurea derivative with the chemical formula C23H28ClN3O5S and a molecular weight of 494.00 g/mol, is a key compound in scientific research. It functions as a potassium channel modulator, specifically targeting voltage-gated ion channels. Its applications span cell biology and neuroscience research, aiding in the investigation of cellular signalling pathways and ion channel function.

IUPAC: 5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide,Glyburide,N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N′-cyclohexylurea
Synonyms: Glyburide5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamideN-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N′-cyclohexylurea

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Glybenclamide (C23H28ClN3O5S) — chemical structure, CAS 10238-21-8; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesCell BiologyIon ChannelsMonovalent Ion ChannelsPotassium Channel ModulatorsRoche

01 /Applications

Potassium Channel Modulation Research

Glybenclamide is widely employed to study the function and regulation of various potassium channels, including those involved in cellular excitability and signaling. Its selective action makes it a valuable tool for dissecting complex physiological processes.

Cellular Signaling Investigations

As a modulator of ion channels, Glybenclamide is instrumental in research aimed at understanding how cellular signaling pathways are influenced by ion flux. This includes studies in neuroscience and cell physiology.

Drug Candidate and Therapeutics Research

Glybenclamide serves as a reference compound and research tool in the development of new therapeutic agents. Its well-defined mechanism of action aids in the screening and validation of potential drug candidates targeting ion channelopathies.

02 /Properties

Molecular weight	494.00
Empirical formula	C23H28ClN3O5S
Assay	≥99% (HPLC)
Solubility	ethanol: soluble2 mg/mLDMSO: solubleH2O: insoluble
Storage temperature	2-8°C
Suitability	meets USP testing specifications

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	2

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

10238-21-8

MDL number

MFCD00056625

PubChem substance

24277838

05 /Additional specifications

Gene Information	human ... KCNH2(3757), KCNJ1(3758), KCNJ11(3767)rat ... Kcnj1(24521)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Glybenclamide used for?

Glybenclamide is used in research as a potassium channel modulator, particularly for voltage-gated ion channels, and in studies of cellular signaling, neuroscience, and as a reference compound in drug discovery for ion channel-related conditions.

What are the CAS number and formula for Glybenclamide?

The CAS number for Glybenclamide is 10238-21-8, and its chemical formula is C23H28ClN3O5S.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Glybenclamide with an assay of ≥99% (HPLC). TSS does not represent this product as USP, BP, or EP grade.

How should Glybenclamide be handled and stored?

Handle Glybenclamide with appropriate personal protective equipment, including eyeshields, gloves, and a P1 (EN143) or N95 respirator. Store at 2-8°C. Refer to the safety data sheet for comprehensive handling information.