5-Fluoro-2-methylphenylmagnesium bromide solution

CAS 186496-59-3FC6H3(CH3)MgBrChemical Synthesis

5-Fluoro-2-methylphenylmagnesium bromide solution (CAS: 186496-59-3), with the linear formula FC₆H₃(CH₃)MgBr and a molecular weight of 213.33 g/mol, is a valuable organometallic reagent. Supplied as a 0.5 M solution in Tetrahydrofuran (THF), this Grignard reagent is primarily utilised in organic synthesis for introducing the 5-fluoro-2-methylphenyl group into various molecular structures, facilitating the creation of complex organic compounds.

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5-Fluoro-2-methylphenylmagnesium bromide solution (FC6H3(CH3)MgBr) — chemical structure, CAS 186496-59-3; Chemistry, fine chemical supplied by Tech Serve Solutions

ArylChemical SynthesisGrignard ReagentsOrganometallic Reagents

01 /Applications

Organic Synthesis Intermediate

Serves as a key building block in multi-step syntheses, enabling the formation of carbon-carbon bonds through reactions with electrophiles. Its specific structure allows for the targeted introduction of fluorinated and methylated aryl moieties into pharmaceutical intermediates and advanced materials.

Pharmaceutical Research and Development

Utilised in the discovery and development of novel drug candidates. The incorporation of fluorine atoms can significantly influence a molecule's pharmacokinetic properties, such as metabolic stability and lipophilicity, making this reagent useful for medicinal chemistry.

Materials Science Applications

Can be employed in the synthesis of specialised polymers and organic electronic materials. The unique electronic properties imparted by the fluorinated aromatic ring are beneficial for creating materials with tailored optical or electrical characteristics.

02 /Properties

Molecular weight	213.33
Linear formula	FC6H3(CH3)MgBr
Boiling point	65 °C
Density	0.960 g/mL at 25 °C
Concentration	0.5 M in THF
Storage temperature	2-8°C

03 /Safety & handling

GHS hazard pictogram: Flammable (GHS02) — Flammable

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Danger

Hazard statements

H225Highly flammable liquid and vapour
H319Causes serious eye irritation
H335May cause respiratory irritation
H351Suspected of causing cancer

Precautionary statements

P210Keep away from heat, sparks and open flames. No smoking
P261Avoid breathing dust, fume, gas or vapours
P281Use personal protective equipment as required
P305IF IN EYES

Flash point	-17 °C / 1.4 °F
Transport (UN / ADR)	UN 2924 8(3) / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	F,Xn
Risk statements (R)	11-19-36/37-40
Safety statements (S)	16-26-36/37
Supplemental hazards	May form explosive peroxides.

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

186496-59-3

MDL number

MFCD01311468

PubChem substance

24879968

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 5-Fluoro-2-methylphenylmagnesium bromide solution used for?

This compound is primarily used as a reagent in organic synthesis to introduce the 5-fluoro-2-methylphenyl group into molecules, particularly in the development of pharmaceuticals and advanced materials.

What is the CAS number and formula for 5-Fluoro-2-methylphenylmagnesium bromide solution?

The CAS number is 186496-59-3 and the linear formula is FC₆H₃(CH₃)MgBr.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this chemical as a 0.5 M solution in THF. We do not specify pharmacopoeia grades unless explicitly stated in the product data. For detailed specifications, please refer to the product's Certificate of Analysis.

How should 5-Fluoro-2-methylphenylmagnesium bromide solution be handled?

This product is a flammable liquid and vapour (H225), causes serious eye irritation (H319), and may cause respiratory irritation (H335). It is also suspected of causing cancer (H351). It may form explosive peroxides. Handle in a well-ventilated area, away from ignition sources, and use appropriate personal protective equipment. Store at 2-8°C.

How is this chemical packed and shipped?

This product is packed and shipped according to international regulations for hazardous materials, including UN 2924 classification. Specific packaging details are available upon request.

How can I request a sample or quote?

Please contact our sales team directly via phone or email to request a sample or a formal quotation for 5-Fluoro-2-methylphenylmagnesium bromide solution.