5-Fluoro-2-methylphenylboronic acid
5-Fluoro-2-methylphenylboronic acid (CAS: 163517-62-2) is an organoboron compound with the formula FC6H3(CH3)B(OH)2 and a molar mass of 153.95 g/mol. This aryl boronic acid serves as a valuable intermediate in organic synthesis. It is primarily employed as a reactant in palladium-catalyzed cross-coupling reactions, particularly the Suzuki-Miyaura coupling, and in the preparation of organometallic reagents.
- IUPAC
- 2-Methyl-5-fluorophenylboronic acid
- Synonyms
- 2-Methyl-5-fluorophenylboronic acid
Suzuki-Miyaura Coupling
5-Fluoro-2-methylphenylboronic acid is a key reagent in Suzuki-Miyaura cross-coupling reactions, facilitating the formation of carbon-carbon bonds. This versatile reaction is widely used in the synthesis of complex organic molecules, including pharmaceuticals and advanced materials.
Organometallic Reagent Preparation
This compound is utilised in the preparation of homoleptic diarylmercurials. These organometallic species can serve as precursors or reagents in various synthetic transformations.
Palladium-Catalyzed Arylation
It acts as a reactant in palladium-phosphine catalysed monoarylation of dibromoarenes. This application enables selective introduction of aryl groups onto aromatic scaffolds.
| Molecular weight | 153.95 |
|---|---|
| Linear formula | FC6H3(CH3)B(OH)2 |
| Application | Reactant for:• Monoarylation of dibromoarenes catalyzed by palladium-phosphine in the presence of potassium carbonate1• Preparation of homoleptic diarylmercurials2• Suzuki-Miyaura coupling3,4 |
| Melting point | 144-148 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Fluoro-2-methylphenylboronic acid used for?
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5-Fluoro-2-methylphenylboronic acid is used as a reactant in chemical synthesis, notably in palladium-catalyzed reactions like the Suzuki-Miyaura coupling and the monoarylation of dibromoarenes, as well as in the preparation of organometallic reagents.
What is the CAS number and chemical formula for 5-Fluoro-2-methylphenylboronic acid?
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The CAS number for 5-Fluoro-2-methylphenylboronic acid is 163517-62-2, and its chemical formula is FC6H3(CH3)B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with a minimum assay of 97%. As this is a research-grade chemical, Tech Serve Solutions does not represent it as USP, BP, or EP.
How should 5-Fluoro-2-methylphenylboronic acid be handled safely?
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Users should wear eyeshields and gloves, and use a type N95 (US) or type P1 (EN143) respirator filter when handling this compound. It is classified as hazardous.
Is 5-Fluoro-2-methylphenylboronic acid a controlled substance?
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Based on the provided data, there is no indication that 5-Fluoro-2-methylphenylboronic acid is a controlled substance.
How is this chemical packed and shipped globally?
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Tech Serve Solutions, as a specialist global supplier and exporter, can provide detailed information on packing and shipping for 5-Fluoro-2-methylphenylboronic acid upon inquiry.
How can I request a sample or quote for 5-Fluoro-2-methylphenylboronic acid?
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To request a sample or a quote for 5-Fluoro-2-methylphenylboronic acid, please contact the TSS sales department via the website or direct contact details.
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