5-Fluoro-2-methylphenylzinc iodide solution
5-Fluoro-2-methylphenylzinc iodide solution (CAS: 312693-09-7; FC₆H₃(CH₃)ZnI; MW: 301.42) is an organozinc halide reagent supplied by Tech Serve Solutions. This solution, typically at 0.5 M in THF, is vital in modern organic synthesis. It serves as a key intermediate for introducing the 5-fluoro-2-methylphenyl group into complex molecules, finding utility in the development of pharmaceuticals and advanced materials through cross-coupling reactions.
Cross-Coupling Reactions
This organozinc reagent is extensively employed in transition-metal-catalysed cross-coupling reactions, such as Negishi coupling. It facilitates the formation of carbon-carbon bonds, enabling the synthesis of biaryl compounds and other complex organic structures.
Pharmaceutical Intermediate Synthesis
It serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates. The incorporation of the fluorinated tolyl moiety can significantly influence a drug's metabolic stability and binding affinity.
Materials Science
The unique electronic properties imparted by the fluoro and methyl substituents make this reagent valuable for synthesising novel organic electronic materials, polymers, and functionalised surfaces.
| Molecular weight | 301.42 |
|---|---|
| Linear formula | FC6H3(CH3)ZnI |
| Boiling point | 65 °C |
| Density | 1.012 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-14-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Fluoro-2-methylphenylzinc iodide solution used for?
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This organozinc reagent is primarily used in organic synthesis for cross-coupling reactions, particularly to introduce the 5-fluoro-2-methylphenyl group into target molecules for pharmaceutical and materials science applications.
What is the CAS number and chemical formula?
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The CAS number is 312693-09-7, and the chemical formula is FC₆H₃(CH₃)ZnI.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 0.5 M solution in THF. We do not represent it as USP, BP, or EP grade unless explicitly stated in the product specifications.
How should 5-Fluoro-2-methylphenylzinc iodide solution be handled?
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Handle with extreme care due to flammability (Flash Point -17 °C) and potential health hazards including eye irritation, respiratory irritation, and possible carcinogenicity. Store in a cool, well-ventilated area away from ignition sources. May form explosive peroxides; take precautions.
Is this product regulated or controlled?
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Based on the provided safety data, this product is classified as highly flammable and a health hazard. Specific controlled substance status is not indicated in the provided data.
How is this chemical packed, shipped, and exported?
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This chemical is shipped under UN 2924 classification (Flammable liquids, corrosive, n.o.s. or Combustible liquids, corrosive, n.o.s., packing group II). TSS is a global supplier and exporter experienced in handling and shipping hazardous materials worldwide.
How can I request a sample or quote?
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Please use the 'Request a Quote' or 'Request a Sample' button on our website or contact our sales team directly with your requirements.
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