5-Fluoro-2′-deoxyuridine
5-Fluoro-2′-deoxyuridine (CAS: 50-91-9; C9H11FN2O5) is a pyrimidine analogue with a molecular weight of 246.19 g/mol. This bioactive small molecule functions as an enzyme inhibitor, specifically targeting thymidylate synthase. It is primarily utilised in biochemical research and cell biology studies as a substrate analog for enzymatic reactions and for investigating cellular processes involving nucleic acid metabolism.
- IUPAC
- 2′-Deoxy-5-fluorouridine,FUDR,Floxuridine
Enzyme Inhibition Studies
5-Fluoro-2′-deoxyuridine acts as a potent inhibitor of thymidylate synthase, a critical enzyme in DNA synthesis. This property makes it valuable for researchers studying enzymatic mechanisms and developing therapeutic strategies targeting rapidly proliferating cells.
Biochemical Research
As a fluorinated pyrimidine nucleoside analog, FUDR is employed in various biochemical investigations. It serves as a tool to probe metabolic pathways, particularly those related to nucleotide metabolism and nucleic acid biosynthesis.
Cell Biology Research
This compound is used in cell culture to study the effects of inhibiting DNA synthesis. Researchers utilise 5-Fluoro-2′-deoxyuridine to investigate cell cycle progression, apoptosis, and the mechanisms of antimetabolite drugs.
Substrate Analog Studies
Its structural similarity to natural deoxyuridine allows 5-Fluoro-2′-deoxyuridine to be used as a substrate analog in studies of enzymes involved in nucleoside and nucleotide metabolism. This helps elucidate enzyme specificity and function.
| Molecular weight | 246.19 |
|---|---|
| Empirical formula | C9H11FN2O5 |
| Melting point | 148 °C(lit.) |
Hazard statements
- H301Toxic if swallowed
Precautionary statements
- P301IF SWALLOWED
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22 |
| Safety statements (S) | 22-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | mouse ... Tyms(22171) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Fluoro-2′-deoxyuridine used for?
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5-Fluoro-2′-deoxyuridine (CAS: 50-91-9) is primarily used in biochemical and cell biology research as an enzyme inhibitor, particularly of thymidylate synthase, and as a substrate analog in studies of nucleic acid metabolism.
What are the CAS number and chemical formula for 5-Fluoro-2′-deoxyuridine?
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The CAS number for 5-Fluoro-2′-deoxyuridine is 50-91-9, and its chemical formula is C9H11FN2O5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Fluoro-2′-deoxyuridine with a purity of 98% by HPLC. We do not represent this product as USP, BP, or EP grade.
How should 5-Fluoro-2′-deoxyuridine be handled safely?
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5-Fluoro-2′-deoxyuridine is classified as acutely toxic (GHS06, Danger, H301). Handle with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, face shields, and gloves. Ensure adequate ventilation and avoid dust formation. Promptly wash if on skin or in eyes, and seek medical attention if swallowed (P301 + P310).
Is 5-Fluoro-2′-deoxyuridine a controlled substance?
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The provided data does not indicate that 5-Fluoro-2′-deoxyuridine is a controlled substance.
How is 5-Fluoro-2′-deoxyuridine packed and shipped?
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5-Fluoro-2′-deoxyuridine is packed and shipped according to UN 2811, Hazard Class 6.1, Packing Group III regulations. Tech Serve Solutions is a global supplier and exporter of this chemical.
How can I request a sample or quote for 5-Fluoro-2′-deoxyuridine?
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To request a sample or a quote for 5-Fluoro-2′-deoxyuridine, please contact our sales team through the website or by phone.
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