5-Chlorothiophene-2-sulfonyl chloride
5-Chlorothiophene-2-sulfonyl chloride (CAS: 2766-74-7; Formula: C4H2Cl2O2S2; MW: 217.09) is a halogenated heterocyclic compound. It serves as a valuable building block in organic synthesis, particularly for introducing the 5-chlorothiophene-2-sulfonyl moiety into more complex molecular structures. This reactive intermediate is crucial for the development of novel compounds within the pharmaceutical and agrochemical industries.

Organic Synthesis Intermediate
This compound functions as a key intermediate in the synthesis of various organic molecules. Its reactive sulfonyl chloride group allows for facile derivatization, enabling the construction of complex structures for research and development.
Pharmaceutical Research
As a heterocyclic building block, 5-Chlorothiophene-2-sulfonyl chloride is employed in the exploratory synthesis of potential drug candidates. The thiophene ring and sulfonyl chloride functionality are common motifs in pharmacologically active compounds.
Agrochemical Development
The compound can be utilised in the design and synthesis of novel agrochemicals, such as pesticides or herbicides. Halogenated heterocycles often exhibit biological activity relevant to crop protection.
Material Science
It may find application in the development of new materials where the incorporation of a thiophene ring system is desired for specific electronic or structural properties.
| Molecular weight | 217.09 |
|---|---|
| Empirical formula | C4H2Cl2O2S2 |
| Assay | 96% |
| Boiling point | 112-117 °C(lit.) |
| Density | 1.623 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.586(lit.) |
| Storage temperature | 2-8°C |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Chlorothiophene-2-sulfonyl chloride used for?
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5-Chlorothiophene-2-sulfonyl chloride is primarily used as a versatile building block in organic synthesis for creating complex molecules, particularly in pharmaceutical and agrochemical research.
What are the CAS number and formula for 5-Chlorothiophene-2-sulfonyl chloride?
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The CAS number is 2766-74-7, and the empirical formula is C4H2Cl2O2S2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Chlorothiophene-2-sulfonyl chloride with a minimum assay of 96%. We do not represent this product as USP, BP, or EP grade.
How should 5-Chlorothiophene-2-sulfonyl chloride be handled safely?
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This compound is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Handling requires appropriate personal protective equipment, including face shields, chemical-resistant gloves, and respiratory protection. Work should be conducted in a well-ventilated area. Refer to the Safety Data Sheet for comprehensive guidance.
How is 5-Chlorothiophene-2-sulfonyl chloride packed and shipped?
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5-Chlorothiophene-2-sulfonyl chloride is packed according to relevant regulations for hazardous materials (UN 3265, Class 8, Packing Group II) and is available for export worldwide by Tech Serve Solutions.
How can I request a quote or sample for 5-Chlorothiophene-2-sulfonyl chloride?
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To request a quote or sample, please contact our sales team via the website or direct email, providing your contact details and the product CAS number (2766-74-7).
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