5-Chloro-2-thienylzinc bromide solution
5-Chloro-2-thienylzinc bromide solution (CAS 312624-22-9), with the empirical formula C4H2BrClSZn and a molecular weight of 262.87 g/mol, is a key organometallic reagent. Supplied as a 0.5 M solution in THF, it is a valuable tool in organic synthesis for introducing the 5-chloro-2-thienyl moiety. This reagent is particularly useful in cross-coupling reactions, enabling the construction of complex molecules containing thiophene rings for pharmaceutical and materials science applications.
Organometallic Synthesis
Used as an organozinc halide reagent in cross-coupling reactions, such as Negishi coupling, to form new carbon-carbon bonds. This facilitates the synthesis of substituted thiophenes.
Heteroaryl Chemistry
Enables the facile introduction of the 5-chloro-2-thienyl group into organic frameworks. This is crucial for the development of novel pharmaceuticals and organic electronic materials.
Pharmaceutical Intermediates
Acts as a building block for the synthesis of complex drug candidates containing the thiophene scaffold, a common motif in many biologically active compounds.
Materials Science
Applicable in the synthesis of functional organic materials, including conjugated polymers and small molecules for organic electronics, where thiophene units are frequently incorporated.
| Molecular weight | 262.87 |
|---|---|
| Empirical formula | C4H2BrClSZn |
| Density | 0.984 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2056 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Chloro-2-thienylzinc bromide solution used for?
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This solution is primarily used in organic synthesis as an organometallic reagent for introducing the 5-chloro-2-thienyl group into molecules, particularly via cross-coupling reactions like Negishi coupling. It serves as a building block in the synthesis of pharmaceuticals and organic materials.
What are the CAS number and formula for this compound?
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The CAS number is 312624-22-9, and the empirical formula is C4H2BrClSZn.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 0.5 M solution in THF. We do not represent it as USP, BP, or EP grade; it is intended for research and chemical synthesis purposes.
How should 5-Chloro-2-thienylzinc bromide solution be handled?
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This solution is flammable (flash point -17 °C) and can form explosive peroxides. Handle in a well-ventilated area, away from ignition sources, and wear appropriate personal protective equipment. Store under refrigeration at 2-8°C.
Is this product shipped internationally?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals and reagents.
How can I request a quote or sample?
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To request a quote or sample, please contact our sales department via the website or by phone, providing the product name and CAS number.
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