5-Chloro-2-thienylboronic acid
5-Chloro-2-thienylboronic acid (CAS 162607-18-3) is an organoboron compound with the molecular formula C4H4BClO2S and a molecular weight of 162.40 g/mol. This heteroaryl boronic acid derivative serves as a valuable reactant in organic synthesis, particularly for palladium-catalysed Suzuki-Miyaura cross-coupling reactions. It is instrumental in the preparation of complex molecules relevant to pharmaceutical and biological research, offering a reliable building block for medicinal chemistry.
- IUPAC
- (5-Chlorothiophen-2-yl)boronic acid,5-Chlorothiophene-2-boronic acid
- Synonyms
- (5-Chlorothiophen-2-yl)boronic acid5-Chlorothiophene-2-boronic acid
Suzuki-Miyaura Cross-Coupling Reactions
Utilise 5-Chloro-2-thienylboronic acid as a coupling partner in palladium-catalysed Suzuki-Miyaura reactions to form new carbon-carbon bonds. This reaction is fundamental in constructing biaryl and heteroaryl systems.
Preparation of Biologically Active Molecules
This boronic acid is a key intermediate for synthesising molecules with potential biological and pharmacological activity. Its structure allows for the introduction of the 5-chlorothiophene moiety into larger, complex frameworks.
Heterocyclic Chemistry
As a functionalised thiophene derivative, it is employed in the synthesis of novel heterocyclic compounds, contributing to the discovery of new chemical entities.
| Molecular weight | 162.40 |
|---|---|
| Empirical formula | C4H4BClO2S |
| Storage temperature | 2-8°C |
| Application | Reactant for:• Suzuki-Miyaura cross-couplings using palladium catalyst1• Preparation of biologically and pharmacologically active molecules2,3,4 |
| Melting point | 136-140 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Chloro-2-thienylboronic acid used for?
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5-Chloro-2-thienylboronic acid (CAS 162607-18-3) is primarily used as a reactant in palladium-catalysed Suzuki-Miyaura cross-coupling reactions and for the preparation of biologically and pharmacologically active molecules.
What is the CAS number and formula for 5-Chloro-2-thienylboronic acid?
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The CAS number is 162607-18-3, and the empirical formula (Hill notation) is C4H4BClO2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Chloro-2-thienylboronic acid as a research-grade chemical. TSS does not represent this product as USP, BP, EP, or other pharmacopoeial grades.
How should 5-Chloro-2-thienylboronic acid be handled?
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Handle 5-Chloro-2-thienylboronic acid with appropriate personal protective equipment, including eyeshields and gloves. Use a type N95 (US) or type P1 (EN143) respirator filter if airborne exposure is possible. Store at 2-8°C.
How is this chemical packed, shipped, and exported?
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Tech Serve Solutions professionally packs, stores, and exports fine chemicals globally, adhering to all necessary regulations for safe and compliant transport.
How can I request a sample or quote for 5-Chloro-2-thienylboronic acid?
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Please contact our sales team via the website or direct email to request a sample or obtain a quotation for 5-Chloro-2-thienylboronic acid.
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