5-Chloro-2-thienylmagnesium bromide
5-Chloro-2-thienylmagnesium bromide (CAS: 111762-30-2) is an organometallic Grignard reagent with the molecular formula C4H2BrClMgS and a molecular weight of 221.79 g/mol. This heteroaryl compound is supplied as a 0.5 M slurry in THF and is primarily used as a building block in organic synthesis, particularly for introducing the 5-chloro-2-thienyl moiety into target molecules.
Organic Synthesis Intermediate
Utilised as a versatile Grignard reagent for carbon-carbon bond formation in the synthesis of complex organic molecules. Its heteroaryl nature makes it valuable for constructing thiophene-containing compounds.
Pharmaceutical Research
Employed in the development of novel pharmaceutical agents where the incorporation of a chlorinated thiophene ring is a key structural feature. Facilitates the creation of diverse chemical libraries for drug discovery.
Materials Science
Serves as a precursor in the synthesis of functional materials, such as organic semiconductors or polymers, where the electronic properties of the thienyl group are advantageous.
| Molecular weight | 221.79 |
|---|---|
| Empirical formula | C4H2BrClMgS |
| Boiling point | 65 °C(lit.) |
| Density | 0.969 g/mL at 25 °C(lit.) |
| Concentration | 0.5 M slurry in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-19-34-37-40 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5-Chloro-2-thienylmagnesium bromide used for?
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5-Chloro-2-thienylmagnesium bromide is primarily used as a Grignard reagent in organic synthesis for the introduction of the 5-chloro-2-thienyl group into organic molecules, finding applications in pharmaceutical research and materials science.
What is the CAS number and formula for 5-Chloro-2-thienylmagnesium bromide?
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The CAS number for 5-Chloro-2-thienylmagnesium bromide is 111762-30-2, and its empirical formula (Hill notation) is C4H2BrClMgS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5-Chloro-2-thienylmagnesium bromide as a 0.5 M slurry in THF. This product is intended for laboratory and research purposes and is not represented as USP, BP, or EP grade.
How should 5-Chloro-2-thienylmagnesium bromide be handled?
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This compound is highly flammable (H225) and corrosive (H314), causing severe skin burns and eye damage. It may form explosive peroxides and reacts violently with water. Handle in a well-ventilated area, away from ignition sources, and wear appropriate personal protective equipment, including gloves, eye protection, and protective clothing. Keep away from water.
How is 5-Chloro-2-thienylmagnesium bromide packed and shipped?
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5-Chloro-2-thienylmagnesium bromide is typically shipped as a regulated hazardous material, UN 2924, Class 8(3), Packing Group II, requiring specialized handling and transportation procedures. It should be stored under refrigeration at 2-8°C.
How can I request a sample or quote for 5-Chloro-2-thienylmagnesium bromide?
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To request a sample or a quote, please contact the Tech Serve Solutions sales team through our website or by phone. Provide the product name and CAS number (111762-30-2) for prompt service.
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