4-(Trifluoromethoxy)benzoyl chloride
4-(Trifluoromethoxy)benzoyl chloride (CAS 36823-88-8) is an organic compound with the linear formula CF3OC6H4COCl and a molecular weight of 224.56 g/mol. This acid halide serves as a valuable building block in organic synthesis. Its primary applications lie in the preparation of various esters, amides, and other derivatives, finding utility in the development of pharmaceuticals, agrochemicals, and advanced materials.
Synthesis of Pharmaceutical Intermediates
This compound is employed as a key intermediate in the multi-step synthesis of complex pharmaceutical agents. It facilitates the introduction of the 4-(trifluoromethoxy)benzoyl moiety into drug candidates, potentially influencing their pharmacokinetic properties.
Agrochemical Development
4-(Trifluoromethoxy)benzoyl chloride is utilised in the creation of novel agrochemicals, such as herbicides and insecticides. The trifluoromethoxy group can enhance the biological activity and stability of these crop protection agents.
Material Science Applications
The compound can be incorporated into polymers and specialty materials. Its unique electronic and structural properties, conferred by the trifluoromethoxy group, make it suitable for advanced material research and development.
Organic Building Block
As a versatile organic building block, it is used in academic and industrial research laboratories for constructing diverse molecular architectures. It enables the synthesis of specialised organic compounds with tailored functionalities.
| Molecular weight | 224.56 |
|---|---|
| Linear formula | CF3OC6H4COCl |
| Assay | 98% |
| Boiling point | 55-56 °C/2 mmHg(lit.) |
| Density | 1.425 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.472(lit.) |
Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 32 °C / 89.6 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Trifluoromethoxy)benzoyl chloride used for?
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4-(Trifluoromethoxy)benzoyl chloride is used as a building block in organic synthesis, particularly for preparing pharmaceutical intermediates, agrochemicals, and advanced materials. It is utilised to introduce the 4-(trifluoromethoxy)benzoyl group into various organic molecules.
What is the CAS number and formula for 4-(Trifluoromethoxy)benzoyl chloride?
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The CAS number is 36823-88-8 and the linear formula is CF3OC6H4COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-(Trifluoromethoxy)benzoyl chloride with an assay of 98%. TSS does not represent this product as USP, BP, or EP grade.
How should 4-(Trifluoromethoxy)benzoyl chloride be handled safely?
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4-(Trifluoromethoxy)benzoyl chloride is a Danger material, indicated by GHS02 and GHS05 symbols. It is flammable (H226) and causes severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment, including gloves, goggles, a face shield, and a suitable respirator. Ensure adequate ventilation and avoid ignition sources. Refer to the Safety Data Sheet for comprehensive handling instructions.
How is this chemical packed, shipped, and exported?
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4-(Trifluoromethoxy)benzoyl chloride is packed according to international shipping regulations for hazardous materials. It is exported globally by Tech Serve Solutions, complying with all relevant transport and customs requirements for UN 2920.
How can I request a sample or a quote for 4-(Trifluoromethoxy)benzoyl chloride?
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To request a sample or a quote, please contact the Tech Serve Solutions sales team through our website or by phone. Provide the product name and CAS number (36823-88-8) for prompt service.
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