D-Ethionine
D-Ethionine (CAS 535-32-0), with the linear formula C2H5SCH2CH2CH(NH2)CO2H and a molecular weight of 163.24 g/mol, is an unnatural amino acid derivative. It is a key building block in chemical biology and peptide chemistry. D-Ethionine is primarily utilised in research settings for its unique biochemical properties, serving as a tool for studying protein synthesis and enzyme inhibition. Its precise applications lie within specialised chemical synthesis and the development of novel biological probes.
- IUPAC
- D-2-Amino-4-(ethylthio)butyric acid

Chemical Biology Research
D-Ethionine serves as a valuable tool in chemical biology for investigating biological processes, particularly protein synthesis and modification. Its unnatural structure allows researchers to probe mechanisms that are distinct from naturally occurring amino acids.
Peptide Synthesis
As an unnatural amino acid derivative, D-Ethionine can be incorporated into synthetic peptides. This enables the creation of novel peptides with altered properties for research in areas like drug discovery and materials science.
Enzyme Inhibition Studies
This compound is used to study the activity and inhibition mechanisms of various enzymes. Its structural similarity to methionine allows it to act as a competitive inhibitor in certain biological pathways.
Chemical Synthesis Intermediate
D-Ethionine functions as a specialised intermediate in complex organic synthesis. It is employed in the preparation of more intricate molecules for advanced research applications.
| Molecular weight | 163.24 |
|---|---|
| Linear formula | C2H5SCH2CH2CH(NH2)CO2H |
| Assay | 98% |
| Optical activity | [α]22/D −21°, c = 1 in 1 M HCl |
| Melting point | 278 °C (dec.)(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is D-Ethionine used for?
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D-Ethionine (CAS 535-32-0) is used in chemical biology research, peptide synthesis, enzyme inhibition studies, and as a specialised intermediate in chemical synthesis.
What are the CAS number and formula for D-Ethionine?
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The CAS number for D-Ethionine is 535-32-0, and its linear formula is C2H5SCH2CH2CH(NH2)CO2H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies D-Ethionine with an assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should D-Ethionine be handled safely?
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D-Ethionine is classified as a warning substance (GHS07) and is indicated for use with a dust mask type N95 (US), eyeshields, and gloves. It may cause skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Handle in a well-ventilated area.
How is D-Ethionine packed and shipped?
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D-Ethionine is packed according to industry standards to ensure safe transit and is exported globally by Tech Serve Solutions.
How can I request a sample or quote for D-Ethionine?
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To request a sample or quote, please contact our sales team through the TSS website or by phone, referencing the product name and CAS number 535-32-0.
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