4-(Trifluoromethoxy)benzonitrile
4-(Trifluoromethoxy)benzonitrile (CAS: 332-25-2), with the molecular formula CF3OC6H4CN and a molecular weight of 187.12 g/mol, is a valuable organic building block. This compound features a nitrile group and a trifluoromethoxy substituent on a benzene ring, offering unique reactivity for chemical synthesis. It is primarily utilised in the development of advanced materials and as an intermediate in the production of pharmaceuticals and agrochemicals.
Pharmaceutical Intermediate
Serves as a crucial building block in the synthesis of various active pharmaceutical ingredients (APIs). Its unique structural features allow for the introduction of trifluoromethoxy and nitrile functionalities into drug candidates.
Agrochemical Synthesis
Employed in the development of novel pesticides, herbicides, and fungicides. The trifluoromethoxy group can impart desirable lipophilicity and metabolic stability to agrochemical compounds.
Materials Science
Utilised in the research and development of advanced organic materials, including liquid crystals and specialty polymers. The electron-withdrawing nature of the substituents influences material properties.
Organic Synthesis Reagent
A versatile intermediate in general organic synthesis, enabling the construction of complex molecular architectures through various chemical transformations.
| Molecular weight | 187.12 |
|---|---|
| Linear formula | CF3OC6H4CN |
| Assay | 98% |
| Boiling point | 192-193 °C(lit.) |
| Density | 1.285 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.452(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 83 °C / 181.4 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(Trifluoromethoxy)benzonitrile used for?
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4-(Trifluoromethoxy)benzonitrile is primarily used as a building block and intermediate in the synthesis of pharmaceuticals, agrochemicals, and advanced organic materials. Its specific reactivity makes it valuable for introducing trifluoromethoxy and nitrile groups into complex molecules.
What is the CAS number and chemical formula for 4-(Trifluoromethoxy)benzonitrile?
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The CAS number for 4-(Trifluoromethoxy)benzonitrile is 332-25-2, and its chemical formula is CF3OC6H4CN.
What grade and purity does Tech Serve Solutions supply for 4-(Trifluoromethoxy)benzonitrile?
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Tech Serve Solutions typically supplies 4-(Trifluoromethoxy)benzonitrile with an assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 4-(Trifluoromethoxy)benzonitrile be handled safely?
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Handling requires appropriate personal protective equipment including eyeshields, face shields, and gloves. Ensure adequate ventilation and use approved respirator filters (e.g., ABEK type). It is classified as harmful if swallowed, in contact with skin, or if inhaled, and causes skin and eye irritation, as well as respiratory irritation.
How is 4-(Trifluoromethoxy)benzonitrile packed and shipped?
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Tech Serve Solutions packages and exports chemicals according to international shipping regulations. Specific packaging details will be provided with your order confirmation. Please note that it is classified as NA 1993 / PGIII for transport.
How can I request a sample or quote for 4-(Trifluoromethoxy)benzonitrile?
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To request a sample or a quote, please contact our sales department via the website or by phone. Provide the product name and CAS number (332-25-2) for prompt service.
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