4-Methoxybenzylzinc chloride solution
4-Methoxybenzylzinc chloride solution (CAS 312693-17-7, C8H9ClOZn, MW 222.00) is a versatile organozinc halide reagent. Supplied as a 0.5 M solution in THF, it is primarily utilised in organic synthesis for cross-coupling reactions and the introduction of the 4-methoxybenzyl group. Its reactivity profile makes it valuable in the construction of complex organic molecules. Tech Serve Solutions provides this reagent for research and development purposes.
Cross-Coupling Reactions
4-Methoxybenzylzinc chloride solution is employed in various palladium-catalysed cross-coupling reactions, such as Negishi couplings. It facilitates the formation of new carbon-carbon bonds by coupling with aryl or vinyl halides and triflates.
Organozinc Reagent
As an organozinc halide, this compound serves as a nucleophilic source of the 4-methoxybenzyl moiety. It can be used in conjugate additions and other organometallic transformations to build more complex molecular architectures.
Synthesis of Pharmaceutical Intermediates
The reagent's ability to introduce the 4-methoxybenzyl group is particularly useful in the multi-step synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
| Molecular weight | 222.00 |
|---|---|
| Linear formula | CH3OC6H4CH2ZnCl |
| Density | 0.958 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2056 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Methoxybenzylzinc chloride solution used for?
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4-Methoxybenzylzinc chloride solution is used as a reagent in organic synthesis, particularly for cross-coupling reactions (e.g., Negishi coupling) and for introducing the 4-methoxybenzyl group into organic molecules, often in the synthesis of pharmaceutical intermediates.
What is the CAS number and formula for 4-Methoxybenzylzinc chloride solution?
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The CAS number is 312693-17-7 and the linear formula is CH3OC6H4CH2ZnCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 0.5 M solution in THF. It is intended for research and development use and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 4-Methoxybenzylzinc chloride solution be handled safely?
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This solution is highly flammable (Flash Point -17 °C) and may form explosive peroxides. It is a skin, eye, and respiratory irritant and is suspected of causing cancer. Handle with appropriate personal protective equipment (gloves, eye protection, respiratory protection) in a well-ventilated area, away from ignition sources. Store under recommended conditions (2-8°C).
How is 4-Methoxybenzylzinc chloride solution packed and shipped?
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This product is classified as UN 2056, Hazard Class 3, Packing Group II, indicating it is shipped as a flammable liquid, likely in specialised containers suitable for hazardous materials, adhering to international shipping regulations for export.
How can I request a sample or quote for 4-Methoxybenzylzinc chloride solution?
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Please contact our sales team via the website or direct email, specifying the product name and CAS number, to request a sample or obtain a quotation.
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