4-Methoxybenzyl-2,2,2-trichloroacetimidate
4-Methoxybenzyl-2,2,2-trichloroacetimidate (CAS 89238-99-3) is a specialized organic compound with the molecular formula C10H10Cl3NO2 and a molecular weight of 282.55 g/mol. This reagent is primarily utilised in organic synthesis for the protection of alcohol functional groups through the formation of p-methoxybenzyl (PMB) ethers. Its specific chemical properties make it a valuable tool in multi-step synthetic procedures within research and development.
- Synonyms
- 89238-99-3
Alcohol Protection as PMB Ethers
This compound serves as a key reagent for the selective protection of alcohol groups. It facilitates the formation of p-methoxybenzyl (PMB) ethers, a widely used protecting group in complex organic synthesis.
Synthetic Reagent
As a versatile synthetic reagent, 4-Methoxybenzyl-2,2,2-trichloroacetimidate is employed in various chemical transformations. It is particularly useful in academic research and industrial laboratories engaged in the synthesis of fine chemicals and pharmaceutical intermediates.
Protecting Group Chemistry
Its application falls under the domain of protecting group chemistry, enabling chemists to temporarily mask hydroxyl functionalities while performing other reactions on a molecule. The PMB ether can be cleaved under specific conditions when protection is no longer required.
| Molecular weight | 282.55 |
|---|---|
| Empirical formula | C10H10Cl3NO2 |
| Boiling point | 135-137 °C/0.7 mmHg |
| Density | 1.361 g/mL at 25 °C |
| Refractive index | n20/D 1.5488 |
| Storage temperature | 2-8°C |
| Impurities tested | Major impurity is Trichloroacetamide by GCMS. |
| Application | Reagent used for the protection of an alcohol as its PMB-ether.1 |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H411Toxic to aquatic life with long-lasting effects
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Flash point | >110 °C / >230 °F |
|---|---|
| Transport (UN / ADR) | UN 3082 9 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 20/21/22-36/37/38-51/53 |
| Safety statements (S) | 26-36/37-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Methoxybenzyl-2,2,2-trichloroacetimidate used for?
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This compound is used as a reagent for the protection of alcohols as their p-methoxybenzyl (PMB) ethers, a common strategy in organic synthesis.
What is the CAS number and molecular formula for this chemical?
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The CAS number is 89238-99-3 and the molecular formula is C10H10Cl3NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical for research and laboratory use. The exact grade and purity are detailed in the product specifications. This product is not represented as USP, BP, EP, or pharmacopoeia grade.
What are the main hazards associated with 4-Methoxybenzyl-2,2,2-trichloroacetimidate?
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This chemical is harmful if swallowed, in contact with skin, or if inhaled. It also causes skin irritation, serious eye irritation, and may cause respiratory irritation. It is also toxic to aquatic life with long lasting effects. Please refer to the Safety Data Sheet for full hazard information and handling precautions.
How is 4-Methoxybenzyl-2,2,2-trichloroacetimidate packed and shipped?
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Tech Serve Solutions exports chemicals globally, adhering to all relevant regulations for safe packing and shipping of hazardous materials. Specific packaging details are available upon request.
How can I request a sample or quote for 4-Methoxybenzyl-2,2,2-trichloroacetimidate?
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To request a sample or a quote, please contact our sales team through the website or by phone, providing the product name and CAS number.
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