4-Methoxybenzyloxycarbonyl azide
4-Methoxybenzyloxycarbonyl azide (CAS 25474-85-5) is an organic azide compound with the molecular formula N3CO2CH2C6H4OCH3 and a molecular weight of 207.19 g/mol. It is primarily utilised as a building block in chemical synthesis and for applications within chemical biology. This reagent is often employed in the preparation of amino acid derivatives and for conjugation chemistry, particularly where the 4-methoxybenzyloxycarbonyl protecting group is desired.
- IUPAC
- 4-Methoxybenzyl azidoformate
- Synonyms
- 4-Methoxybenzyl azidoformate
Synthesis of Protected Amino Acids
4-Methoxybenzyloxycarbonyl azide serves as a key reagent for introducing the 4-methoxybenzyloxycarbonyl (Mcb) protecting group onto amino acids. For example, it has been used in the preparation of N-4-methoxybenzyloxycarbonyl-L-α-aminoadipic acid.
Chemical Biology Research
The compound is valuable in chemical biology for creating modified biomolecules. Its azide functionality allows for participation in click chemistry reactions, enabling the labelling or functionalisation of biological targets.
Organic Synthesis Building Block
As a versatile building block, 4-Methoxybenzyloxycarbonyl azide is employed in various organic synthesis pathways. Its structure allows for the introduction of the Mcb group, which can be useful in multi-step syntheses of complex molecules.
| Molecular weight | 207.19 |
|---|---|
| Linear formula | N3CO2CH2C6H4OCH3 |
| Assay | 95% |
| Storage temperature | 2-8°C |
| Application | 4-Methoxybenzyloxycarbonyl azide was used to prepare N-4-methoxybenzyloxycarbonyl-L-α-aminoadipic acid1. |
| Melting point | 30-32 °C(lit.) |
Hazard statements
- H272May intensify fire; oxidiser
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H332Harmful if inhaled
Precautionary statements
- P220Keep away from clothing and combustible materials
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 1479 5.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 5-20/21/22 |
| Safety statements (S) | 36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Methoxybenzyloxycarbonyl azide used for?
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4-Methoxybenzyloxycarbonyl azide is used as a building block in chemical synthesis, particularly in chemical biology and for the preparation of protected amino acid derivatives. It is utilised for introducing the 4-methoxybenzyloxycarbonyl protecting group.
What are the CAS number and formula for 4-Methoxybenzyloxycarbonyl azide?
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The CAS number for 4-Methoxybenzyloxycarbonyl azide is 25474-85-5 and its linear formula is N3CO2CH2C6H4OCH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Methoxybenzyloxycarbonyl azide with a purity of 95% (assay). We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 4-Methoxybenzyloxycarbonyl azide be handled?
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4-Methoxybenzyloxycarbonyl azide is a hazardous substance classified with Signal Word 'Danger' and H-statements H272 (May intensify fire; oxidiser), H302 (Harmful if swallowed), H312 (Harmful in contact with skin), and H332 (Harmful if inhaled). Handle with appropriate personal protective equipment including eyeshields, gloves, and a dust mask type N95 (US). Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. Keep away from clothing and other combustible materials. Store in accordance with safety data sheet recommendations.
Is 4-Methoxybenzyloxycarbonyl azide a controlled substance?
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The provided data does not indicate that 4-Methoxybenzyloxycarbonyl azide is a controlled substance.
How is 4-Methoxybenzyloxycarbonyl azide packed and shipped?
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This product is classified under UN 1479, Hazard Class 5.1 (Oxidiser), Packing Group II. It is packed and exported in compliance with all relevant transport regulations.
How can I request a sample or quote for 4-Methoxybenzyloxycarbonyl azide?
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To request a sample or a quote for 4-Methoxybenzyloxycarbonyl azide, please contact our sales department through the website or by telephone.
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