4-Methoxybenzyl chloride
4-Methoxybenzyl chloride (CAS: 824-94-2; Formula: CH3OC6H4CH2Cl) is a chemical compound with a molecular weight of 156.61 g/mol. This organic building block, often stabilised with potassium carbonate, is primarily used in organic synthesis. It serves as a versatile reagent for introducing the 4-methoxybenzyl group in various chemical transformations, finding utility in the preparation of complex organic molecules and pharmaceutical intermediates.
- IUPAC
- 4-(Chloromethyl)anisole
Nitrogen Benzylation
4-Methoxybenzyl chloride can be employed to benzylate aniline nitrogen atoms, a key step in the synthesis of various amine derivatives.
Synthesis of Heterocycles
It is used in the synthesis of compounds like 1-naphthamide, contributing to the construction of heterocyclic ring systems.
Suzuki Cross-Coupling Reactions
This compound participates in Suzuki cross-coupling reactions with potassium aryltrifluoroborates, enabling the formation of diarylmethanes.
| Molecular weight | 156.61 |
|---|---|
| Linear formula | CH3OC6H4CH2Cl |
| Assay | 98% |
| Boiling point | 117-118 °C/14 mmHg(lit.) |
| Density | 1.155 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.548(lit.) |
| Storage temperature | 2-8°C |
| Melting point | −1 °C(lit.) |
| Contains / stabiliser | potassium carbonate as stabilizer |
| Application | 4-Methoxybenzyl chloride was used to benzylate the aniline nitrogen1. It was also used in the synthesis of 1-naphthamide2 and diarymethanes via Suzuki cross-coupling with postassium aryltrifluoroborates3. |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 109 °C / 228.2 °F |
| Transport (UN / ADR) | UN 3265 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Methoxybenzyl chloride used for?
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4-Methoxybenzyl chloride is primarily used as a building block in organic synthesis for introducing the 4-methoxybenzyl group, for example, in nitrogen benzylation, synthesis of 1-naphthamide, and diarylmethanes via Suzuki cross-coupling.
What is the CAS number and chemical formula for 4-Methoxybenzyl chloride?
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The CAS number for 4-Methoxybenzyl chloride is 824-94-2, and its chemical formula is CH3OC6H4CH2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Methoxybenzyl chloride at a purity of 98%. We do not represent this product as USP, BP, or EP grade.
How should 4-Methoxybenzyl chloride be handled?
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4-Methoxybenzyl chloride is a Danger hazard (H314 - Causes severe skin burns and eye damage). Handle with appropriate personal protective equipment including faceshields, gloves, goggles, and a suitable respirator. Store at 2-8°C.
Is 4-Methoxybenzyl chloride packed and shipped globally by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals including 4-Methoxybenzyl chloride.
How can I request a sample or quote for 4-Methoxybenzyl chloride?
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To request a sample or quote, please contact our sales team via the website or your designated account manager.
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