4-Methoxybenzoyl chloride
4-Methoxybenzoyl chloride (CAS: 100-07-2), with the linear formula CH₃OC₆H₄COCl and a molecular weight of 170.59 g/mol, is a reactive acyl chloride. It serves as a valuable intermediate and building block in organic synthesis. Commonly employed in derivatisation reactions, particularly for analytical purposes such as HPLC, it is also utilised in chemical synthesis for introducing the 4-methoxybenzoyl group into various molecules.
- IUPAC
- p-Anisoyl chloride
- Synonyms
- p-Anisoyl chloride4-Anisoyl chlorideBenzoyl chloride, 4-methoxy-
Organic Synthesis Intermediate
As a functionalised aromatic acid chloride, 4-Methoxybenzoyl chloride is widely used as a building block in the synthesis of more complex organic molecules. It readily reacts with nucleophiles like alcohols and amines to form esters and amides respectively.
Derivatisation Reagent
This compound is employed as a derivatising agent, especially in analytical chemistry. Its reaction with specific analytes can improve their detectability or separability, for instance, in High-Performance Liquid Chromatography (HPLC) applications.
Analytical Reagent
4-Methoxybenzoyl chloride is utilised in various analytical procedures. Its reactivity allows for the modification of sample components to facilitate spectroscopic or chromatographic analysis, including UV-VIS detection.
| Molecular weight | 170.59 |
|---|---|
| Linear formula | CH3OC6H4COCl |
| Assay | 99% |
| Boiling point | 262-263 °C(lit.) |
| Density | 1.260 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.581(lit.) |
| Melting point | 22 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 87 °C / 188.6 °F |
| Transport (UN / ADR) | UN 1729 8 / PGII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34 |
| Safety statements (S) | 26-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Methoxybenzoyl chloride used for?
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4-Methoxybenzoyl chloride is primarily used as a building block in organic synthesis and as a derivatisation reagent in analytical chemistry, particularly for HPLC and UV-VIS analysis.
What are the CAS number and formula for 4-Methoxybenzoyl chloride?
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The CAS number is 100-07-2, and its linear formula is CH₃OC₆H₄COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Methoxybenzoyl chloride with a minimum assay of 99%. This product is not represented as USP, BP, or EP grade.
How should 4-Methoxybenzoyl chloride be handled safely?
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4-Methoxybenzoyl chloride is a corrosive substance that reacts violently with water. Handle with extreme care, using appropriate personal protective equipment including gloves, eye protection (goggles and face shield), and respiratory protection suitable for acid chlorides.
How is 4-Methoxybenzoyl chloride packed and shipped?
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This chemical is classified under UN 1729, hazard class 8, packing group II. TSS ensures safe and compliant packaging and export of this material worldwide.
How can I request a sample or quote for 4-Methoxybenzoyl chloride?
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To request a sample or obtain a quotation, please contact our sales team through the website or by phone, specifying your requirements for 4-Methoxybenzoyl chloride (CAS 100-07-2).
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