4-Fluorobenzyl isocyanate
4-Fluorobenzyl isocyanate (CAS: 132740-43-3; Formula: FC6H4CH2NCO; MW: 151.14) is a reactive organic building block. It is primarily utilised in chemical synthesis for the introduction of the 4-fluorobenzyl moiety into various organic structures. This compound serves as a key intermediate in the development of novel materials and pharmaceutical candidates, owing to the unique properties imparted by the fluorine atom and the isocyanate functional group.
Organic Synthesis Intermediate
4-Fluorobenzyl isocyanate is employed as a versatile intermediate in complex organic syntheses. Its reactive isocyanate group readily undergoes addition reactions with nucleophiles, facilitating the construction of substituted ureas, carbamates, and amides.
Pharmaceutical Research
This compound is valuable in medicinal chemistry for synthesising potential drug candidates. The incorporation of a fluorobenzyl group can influence a molecule's lipophilicity, metabolic stability, and binding affinity to biological targets.
Materials Science
It can be used in the development of specialised polymers and functional materials. The presence of fluorine can modify material properties such as thermal stability, chemical resistance, and surface characteristics.
| Molecular weight | 151.14 |
|---|---|
| Linear formula | FC6H4CH2NCO |
| Assay | 98% |
| Boiling point | 211 °C(lit.) |
| Density | 1.186 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.505(lit.) |
| Storage temperature | −20°C |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 93 °C / 199.4 °F |
| Transport (UN / ADR) | UN 2206 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluorobenzyl isocyanate used for?
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4-Fluorobenzyl isocyanate is primarily used as an intermediate in organic synthesis, particularly in the development of pharmaceuticals and advanced materials, due to its reactive isocyanate group and the presence of a fluorobenzyl moiety.
What are the CAS number and formula for 4-Fluorobenzyl isocyanate?
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The CAS number for 4-Fluorobenzyl isocyanate is 132740-43-3, and its chemical formula is FC6H4CH2NCO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Fluorobenzyl isocyanate with a minimum purity of 98%. This product is typically considered for research and chemical synthesis purposes and is not represented as USP, BP, or EP grade.
How should 4-Fluorobenzyl isocyanate be handled safely?
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4-Fluorobenzyl isocyanate is a warning substance (GHS07) and is harmful if swallowed, in contact with skin, or if inhaled. It also causes skin and serious eye irritation and may cause respiratory irritation. Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, must be used. Handle in a well-ventilated area.
How is 4-Fluorobenzyl isocyanate packed and shipped?
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4-Fluorobenzyl isocyanate is typically stored at -20°C. Packaging and shipping comply with international regulations for hazardous materials, including UN 2206, hazard class 6.1, and packing group III.
How can I request a quote or sample for 4-Fluorobenzyl isocyanate?
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To request a quote or sample, please contact the Tech Serve Solutions sales team through our website or by telephone, providing your specific requirements.
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