4-Fluorobenzylmagnesium chloride
4-Fluorobenzylmagnesium chloride (CAS: 1643-73-8), with the linear formula FC<sub>6</sub>H<sub>4</sub>CH<sub>2</sub>MgCl and a molecular weight of 168.88 g/mol, is a reactive organometallic compound. It serves as a valuable building block in organic synthesis, particularly for introducing the 4-fluorobenzyl group. This Grignard reagent is primarily employed in the construction of complex organic molecules and pharmaceutical intermediates. Supplied as a 0.25 M solution in Tetrahydrofuran (THF).
Organofluorine Synthesis
Utilised as a key reagent for introducing the 4-fluorobenzyl moiety into organic structures. This is crucial in the synthesis of fluorinated pharmaceuticals and agrochemicals.
Pharmaceutical Intermediate Production
Serves as a building block in the multi-step synthesis of active pharmaceutical ingredients (APIs). Its reactivity allows for the formation of carbon-carbon bonds essential in drug discovery and development.
Material Science Research
Can be employed in the development of novel organic materials where specific fluorinated benzyl functionalities are required to impart desired electronic or physical properties.
Fine Chemical Manufacturing
Acts as a versatile intermediate in the custom synthesis of specialised fine chemicals. Its Grignard nature enables a range of nucleophilic addition and substitution reactions.
| Molecular weight | 168.88 |
|---|---|
| Linear formula | FC6H4CH2MgCl |
| Boiling point | 65 °C(lit.) |
| Density | 0.910 g/mL at 25 °C(lit.) |
| Concentration | 0.25 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US) |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-14-19-36/37/38-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluorobenzylmagnesium chloride used for?
+
4-Fluorobenzylmagnesium chloride is primarily used as a reagent in organic synthesis for introducing the 4-fluorobenzyl group, particularly in the preparation of pharmaceutical intermediates and fluorinated organic compounds.
What is the CAS number and formula for 4-Fluorobenzylmagnesium chloride?
+
The CAS number is 1643-73-8 and the linear formula is FC<sub>6</sub>H<sub>4</sub>CH<sub>2</sub>MgCl.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 4-Fluorobenzylmagnesium chloride as a 0.25 M solution in Tetrahydrofuran (THF). TSS does not represent this product as USP, BP, or EP grade.
How should 4-Fluorobenzylmagnesium chloride be handled safely?
+
This compound is highly reactive and flammable (H225). It causes severe skin burns and eye damage (H314) and may cause respiratory irritation (H335). It reacts violently with water and may form explosive peroxides. Always handle under an inert atmosphere, avoid contact with water and air, and wear appropriate personal protective equipment, including gloves, eye protection, and respiratory protection.
Is 4-Fluorobenzylmagnesium chloride shipped internationally?
+
Yes, Tech Serve Solutions is a specialist global supplier and exporter of chemicals and can export 4-Fluorobenzylmagnesium chloride worldwide, adhering to all relevant shipping regulations.
How can I request a quote or sample?
+
To request a quote or sample for 4-Fluorobenzylmagnesium chloride, please contact our sales team through the website or by calling our main office. Please specify the quantity required and your shipping destination.
What are the storage recommendations for this chemical?
+
4-Fluorobenzylmagnesium chloride should be stored under an inert atmosphere at 2-8°C to maintain its stability and reactivity. Ensure containers are tightly sealed.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis