4-Fluorobenzylzinc chloride solution
4-Fluorobenzylzinc chloride solution (CAS 312693-07-5) is an organozinc halide reagent with the linear formula FC₆H₄CH₂ZnCl and a molecular weight of 209.96. Supplied as a 0.5 M solution in THF, this compound is valuable in organic synthesis for its ability to participate in various coupling reactions. It is commonly employed in the formation of carbon-carbon bonds, facilitating the synthesis of complex organic molecules and pharmaceutical intermediates.
Cross-Coupling Reactions
This organozinc reagent is widely used in transition-metal-catalyzed cross-coupling reactions, such as Negishi coupling, to form new carbon-carbon bonds. It enables the introduction of the 4-fluorobenzyl group into diverse organic structures.
Organic Synthesis
It serves as a versatile building block in complex molecule synthesis. Its reactivity profile makes it suitable for incorporating the fluorinated benzyl moiety into target compounds, often found in medicinal chemistry.
Pharmaceutical Intermediate Synthesis
The compound is instrumental in the preparation of various pharmaceutical intermediates. The presence of the fluorine atom can influence the pharmacokinetic properties of potential drug candidates.
| Molecular weight | 209.96 |
|---|---|
| Linear formula | FC6H4CH2ZnCl |
| Density | 0.952 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Transport (UN / ADR) | UN 2056 3 / PGII |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 19-36/37-40 |
| Safety statements (S) | 26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluorobenzylzinc chloride solution used for?
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4-Fluorobenzylzinc chloride solution is primarily used in organic synthesis, particularly for cross-coupling reactions like Negishi coupling, to introduce the 4-fluorobenzyl group into organic molecules. It is also a key reagent in the synthesis of pharmaceutical intermediates.
What is the CAS number and formula for 4-Fluorobenzylzinc chloride solution?
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The CAS number is 312693-07-5, and its linear formula is FC₆H₄CH₂ZnCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Fluorobenzylzinc chloride solution at a concentration of 0.5 M in THF. TSS does not represent this product as USP, BP, or EP grade.
How should 4-Fluorobenzylzinc chloride solution be handled?
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This solution is a Warning substance (GHS07, GHS08) and may form explosive peroxides. Handle with appropriate personal protective equipment (P261, P281, P305 + P351 + P338) in a well-ventilated area. Avoid contact with skin and eyes and do not breathe vapour (H319, H335).
How is 4-Fluorobenzylzinc chloride solution packed and shipped?
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This product is classified under UN 2056, Class 3, Packing Group II. It is shipped according to relevant dangerous goods regulations and stored at 2-8°C to maintain stability.
How can I request a quote or sample?
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To request a quote or a sample of 4-Fluorobenzylzinc chloride solution, please contact the Tech Serve Solutions sales team via our website or directly by phone.
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