4-Fluorobenzyl bromide
4-Fluorobenzyl bromide (CAS: 459-46-1; Formula: FC6H4CH2Br; MW: 189.02) is a fluorinated organic building block. This aryl halide serves as a valuable intermediate in chemical synthesis, particularly for introducing the 4-fluorobenzyl group into organic molecules. It finds application in the preparation of various complex organic compounds for research and development purposes.
- IUPAC
- α-Bromo-4-fluorotoluene,1-Bromomethyl-4-fluorobenzene
- Synonyms
- α-Bromo-4-fluorotoluene1-Bromomethyl-4-fluorobenzene
Synthesis of Indole Derivatives
4-Fluorobenzyl bromide is utilized in the synthesis of substituted indoles, such as 3-acetyl-1-(4-fluorobenzyl)-4-hydroxy-1H-indole. This application highlights its role in constructing heterocyclic ring systems common in medicinal chemistry.
Preparation of Isatin Compounds
This compound serves as a key reactant in the preparation of functionalized isatins, including 1-(4-fluorobenzyl)-5-(pyrrolidine-1-sulfonyl)isatin and its chiral analogue. These derivatives are important scaffolds in drug discovery.
Adenine Derivative Synthesis
4-Fluorobenzyl bromide is employed in the synthesis of brominated adenine derivatives, specifically 8-bromo 9-(4-fluorobenzyl) adenine and 8-bromo 3-(4-fluorobenzyl) adenine. These reactions demonstrate its utility in modifying nucleobase structures.
| Molecular weight | 189.02 |
|---|---|
| Linear formula | FC6H4CH2Br |
| Assay | 97% |
| Boiling point | 85 °C/15 mmHg(lit.) |
| Density | 1.517 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.547(lit.) |
| Application | 4-Fluorobenzyl bromide was used in the preparation of:• 3-acetyl-1-(4-fluorobenzyl)-4-hydroxy-1H-indole1• 1-(4-fluorobenzyl)-5-(pyrrolidine-1-sulfonyl)isatin2• (S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)pyrrolidine-1-sulfonyl)isatin2• 8-bromo 9-(4-fluorobenzyl) adenine3• 8-bromo 3-(4-fluorobenzyl) adenine3 |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | >113 °C / >235.4 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluorobenzyl bromide used for?
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4-Fluorobenzyl bromide is used as a chemical intermediate in organic synthesis, particularly for introducing the 4-fluorobenzyl moiety in the preparation of indole, isatin, and adenine derivatives.
What are the CAS number and formula for 4-Fluorobenzyl bromide?
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The CAS number for 4-Fluorobenzyl bromide is 459-46-1, and its chemical formula is FC6H4CH2Br.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Fluorobenzyl bromide with an assay of 97%. It is supplied for research and development purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 4-Fluorobenzyl bromide be handled safely?
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4-Fluorobenzyl bromide is classified as Danger, with hazard statement H314 (Causes severe skin burns and eye damage). It requires stringent safety precautions including the use of full-face respirators, chemical-resistant gloves, and eye protection. Handle in a well-ventilated area and avoid contact with skin, eyes, and clothing.
Is 4-Fluorobenzyl bromide exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 4-Fluorobenzyl bromide.
How can I request a sample or quote for 4-Fluorobenzyl bromide?
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To request a sample or quote for 4-Fluorobenzyl bromide, please contact our sales team through the website or by phone, providing your specific requirements.
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