4-Fluorobenzoyl chloride

CAS 403-43-0FC6H4COClChemical Synthesis

4-Fluorobenzoyl chloride (CAS 403-43-0) is a fluorinated organic building block with the linear formula FC6H4COCl and a molecular weight of 158.56 g/mol. This acid halide is primarily utilised in organic synthesis as a versatile acylating agent. Its applications are found in the preparation of complex organic molecules, including specialty polymers and pharmaceutical intermediates, owing to the presence of the reactive benzoyl chloride moiety and the fluorine atom.

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4-Fluorobenzoyl chloride (FC6H4COCl) — chemical structure, CAS 403-43-0; Chemistry, fine chemical supplied by Tech Serve Solutions

Acid HalidesBuilding BlocksCarbonyl CompoundsChemical SynthesisFluorinated Building BlocksOrganic Building Blocks

01 /Applications

Synthesis of Fluorinated Ketones

4-Fluorobenzoyl chloride is employed in Friedel-Crafts acylation reactions to synthesise fluorinated aromatic ketones, such as 4-Fluoro-4′-N,N-dimethylaminobenzophenone. These intermediates can be valuable in the development of dyes and electronic materials.

Preparation of Electroactive Polyamides

This compound has been utilised in the synthesis of novel electroactive polyamides. These polymers incorporate fluorinated aromatic units and azo groups, contributing to their unique electronic and conductive properties for advanced material applications.

Building Block in Organic Synthesis

As a key aryl fluorinated building block, 4-Fluorobenzoyl chloride serves as a reactive intermediate for introducing the 4-fluorobenzoyl group into various organic structures. This is critical for developing new chemical entities in research and development.

02 /Properties

Molecular weight	158.56
Linear formula	FC6H4COCl
Assay	98%
Boiling point	82 °C/20 mmHg(lit.)
Density	1.342 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.532(lit.)
Application	4-Fluorobenzoyl chloride was used in the preparation of 4-Fluoro-4′-N,N-dimethylaminobenzophenone1. It was used in the synthesis of a novel electroactive polyamide with alternating amino-capped aniline pentamer and azo groups in the main chain2.
Melting point	10-12 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Corrosive (GHS05) — Corrosive

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection
P305IF IN EYES
P310Immediately call a POISON CENTER or doctor

Protective equipment	Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Flash point	82 °C / 179.6 °F
Transport (UN / ADR)	UN 3265 8 / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	C
Risk statements (R)	34
Safety statements (S)	26-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

403-43-0

MDL number

MFCD00000684

PubChem substance

24847304

Beilstein registry

386215

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 4-Fluorobenzoyl chloride used for?

4-Fluorobenzoyl chloride is used as a building block in organic synthesis, particularly for preparing fluorinated ketones and electroactive polyamides.

What is the CAS number and formula for 4-Fluorobenzoyl chloride?

The CAS number is 403-43-0 and the linear formula is FC6H4COCl.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 4-Fluorobenzoyl chloride with an assay of 98%. We do not represent this product as USP, BP, or EP grade.

What are the main hazards associated with 4-Fluorobenzoyl chloride?

4-Fluorobenzoyl chloride is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including gloves, goggles, and respiratory protection, is essential when handling this corrosive material.

How is 4-Fluorobenzoyl chloride packed, shipped, and exported?

4-Fluorobenzoyl chloride is packaged and shipped in compliance with all relevant transportation regulations for hazardous materials, including UN 3265. We export globally to meet research and industrial needs.

How can I request a quote or sample of 4-Fluorobenzoyl chloride?

To request a quote or a sample of 4-Fluorobenzoyl chloride, please contact our sales department via the website or direct email, providing your specific requirements.