4-Fluoro-3-cyanobenzenesulfonyl chloride
4-Fluoro-3-cyanobenzenesulfonyl chloride (CAS: 351003-23-1; Formula: FC6H3(CN)SO2Cl; Molar Mass: 219.62 g/mol) is a specialised aryl fluorinated building block. This reactive sulfonyl chloride derivative is primarily employed as an intermediate in organic synthesis, particularly for the introduction of fluorinated and cyano-substituted benzenesulfonyl moieties into more complex molecules. Its applications span research and development in pharmaceuticals, agrochemicals, and materials science.

Organic Synthesis Intermediate
Serves as a versatile building block for constructing complex organic molecules. The presence of both fluorine and a cyano group on the benzene ring, along with the reactive sulfonyl chloride functionality, makes it valuable for diverse synthetic pathways.
Pharmaceutical Research
Used in the development of novel pharmaceutical candidates. Fluorinated aromatic compounds are frequently incorporated into drug structures to modulate properties such as metabolic stability, lipophilicity, and binding affinity.
Agrochemical Development
A potential intermediate in the synthesis of new agrochemical agents. Fluorine incorporation can enhance the efficacy and persistence of pesticides and herbicides.
Materials Science
Explored for use in the creation of advanced materials. Fluorinated organic compounds can impart unique electronic or physical properties to polymers and other materials.
| Molecular weight | 219.62 |
|---|---|
| Linear formula | FC6H3(CN)SO2Cl |
| Assay | 97% |
| Melting point | 67-70 °C(lit.) |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluoro-3-cyanobenzenesulfonyl chloride used for?
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4-Fluoro-3-cyanobenzenesulfonyl chloride is primarily used as an intermediate in organic synthesis for pharmaceuticals, agrochemicals, and materials science. Its structure allows for the introduction of fluorinated and cyano-substituted benzenesulfonyl groups into target molecules.
What is the CAS number and chemical formula?
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The CAS number for 4-Fluoro-3-cyanobenzenesulfonyl chloride is 351003-23-1, and its linear chemical formula is FC6H3(CN)SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Fluoro-3-cyanobenzenesulfonyl chloride with an assay of 97%. This compound is supplied for research and development purposes and is not represented as USP, BP, or EP grade.
How should 4-Fluoro-3-cyanobenzenesulfonyl chloride be handled?
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This compound is classified as Danger with hazard statement H314 (Causes severe skin burns and eye damage). Handling requires appropriate personal protective equipment, including eyeshields, face shields, gloves, and suitable respiratory protection. Always consult the Safety Data Sheet (SDS) before use.
Is this chemical packed, shipped, or exported internationally?
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Yes, Tech Serve Solutions, as a specialist global supplier and exporter since 1998, packs, ships, and exports fine chemicals like 4-Fluoro-3-cyanobenzenesulfonyl chloride.
How can I request a sample or quote?
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To request a sample or a quote for 4-Fluoro-3-cyanobenzenesulfonyl chloride, please contact our sales department through the website or by phone, providing your specific requirements.
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