4-Fluoro-3-(trifluoromethyl)phenyl isocyanate
4-Fluoro-3-(trifluoromethyl)phenyl isocyanate (CAS: 139057-86-6), with the molecular formula FC6H3(CF3)NCO and a molecular weight of 205.11 g/mol, is a fluorinated organic building block. This isocyanate derivative serves as a key intermediate in various chemical synthesis processes, particularly in the development of novel organic compounds. Its reactivity makes it valuable for introducing fluorinated trifluoromethylphenyl moieties into larger molecular structures.
Pharmaceutical Intermediate Synthesis
Utilised in the multi-step synthesis of active pharmaceutical ingredients (APIs) where fluorinated aromatic structures are desired for modulating drug properties.
Agrochemical Development
Serves as a building block for the creation of new pesticides and herbicides, leveraging the unique electronic effects of fluorine and trifluoromethyl groups.
Material Science Research
Employed in the development of advanced polymers and specialty materials, where its incorporation can impart specific thermal or chemical resistance characteristics.
Organic Synthesis Reagent
Acts as a reactive intermediate for creating diverse organic molecules, including heterocycles and amides, through reactions involving the isocyanate functional group.
| Molecular weight | 205.11 |
|---|---|
| Linear formula | FC6H3(CF3)NCO |
| Assay | 97% |
| Boiling point | 48 °C/1 mmHg(lit.) |
| Density | 1.44 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.461(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 80 °C / 176 °F |
| Transport (UN / ADR) | UN 2922 8/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluoro-3-(trifluoromethyl)phenyl isocyanate used for?
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4-Fluoro-3-(trifluoromethyl)phenyl isocyanate is primarily used as a versatile building block in organic synthesis, finding applications in the development of pharmaceuticals, agrochemicals, and specialty materials.
What is the CAS number and formula for this chemical?
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The CAS number is 139057-86-6 and the linear formula is FC6H3(CF3)NCO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of 97%. TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated.
How should 4-Fluoro-3-(trifluoromethyl)phenyl isocyanate be handled safely?
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This compound is classified under GHS07 with a Warning signal word, presenting hazards H302, H312, H315, H319, H332, and H335. Appropriate personal protective equipment, including eyeshields, face shields, gloves, and a suitable respirator, must be worn. Handle in a well-ventilated area, avoiding contact with skin, eyes, and clothing.
Is this chemical available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 4-Fluoro-3-(trifluoromethyl)phenyl isocyanate.
How can I request a quote or sample?
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To request a quote or sample, please contact our sales team through the provided contact channels on our website, specifying the product name and CAS number.
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