4-Fluoro-3-formylphenylboronic acid
4-Fluoro-3-formylphenylboronic acid (CAS: 374538-01-9; Formula: C7H6BFO3; MW: 167.93) is a functionalised aryl boronic acid and an organic building block. It serves as a versatile reactant in organic synthesis, particularly in cross-coupling reactions. This compound is employed in the preparation of complex molecules, including potential pharmaceutical intermediates and biologically active compounds, utilising its aldehyde and boronic acid functionalities for further chemical elaboration.
Preparation of Arylmethylpyrrolidinylmethanols
Utilised as a reactant in the preparation of arylmethylpyrrolidinylmethanols and their amine derivatives. This involves initial reaction with MIDA followed by a Suzuki coupling with halides or amination with amines.
Synthesis of MMP-12 Inhibitors
Applied in the synthesis of N-(biarylsulfonyl) $\alpha$-amino acids, which are investigated as matrix metalloproteinase-12 (MMP-12) inhibitors. This process can be guided by genetic algorithms.
Regioselective Suzuki-Miyaura Coupling
Serves as a precursor for para-substituted formylarylboronic esters. These esters are used in regioselective Suzuki-Miyaura cross-coupling reactions, for example, with bromobenzene.
| Molecular weight | 167.93 |
|---|---|
| Empirical formula | C7H6BFO3 |
| Assay | ≥95% |
| Storage temperature | 2-8°C |
| Application | Reactant for:• Preparation of arylmethylpyrrolidinylmethanols and amine derivatives via reaction with MIDA, followed by Suzuki reaction with halides or amination with amines1• Preparation of N-(biarylsulfonyl) a-amino acids as MMP-12 inhibitors using a genetic algorithm2• Preparation of para-substituted formylarylboronic esters for regioselective Suzuki-Miyaura cross-coupling with bromobenzene3 |
| Melting point | 215-220 °C |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluoro-3-formylphenylboronic acid used for?
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4-Fluoro-3-formylphenylboronic acid is used as a reactant in organic synthesis for preparing various complex molecules. Specific applications include the synthesis of arylmethylpyrrolidinylmethanols, N-(biarylsulfonyl) $\alpha$-amino acids as MMP-12 inhibitors, and in regioselective Suzuki-Miyaura cross-coupling reactions.
What are the CAS number and formula for 4-Fluoro-3-formylphenylboronic acid?
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The CAS number is 374538-01-9, and the empirical formula is C7H6BFO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Fluoro-3-formylphenylboronic acid with an assay of $\ge$95%. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling requirements for this chemical?
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4-Fluoro-3-formylphenylboronic acid is classified as hazardous. Please consult the Safety Data Sheet (SDS) for detailed information on hazards, handling, storage, and personal protective equipment. It has a WGK Germany classification of 3.
How is 4-Fluoro-3-formylphenylboronic acid shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, and we handle the packing, shipping, and export of 4-Fluoro-3-formylphenylboronic acid in compliance with all relevant regulations.
How can I request a sample or quote for 4-Fluoro-3-formylphenylboronic acid?
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To request a sample or a quotation for 4-Fluoro-3-formylphenylboronic acid, please contact our sales team through the website or by phone.
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