4-Fluoro-3-(trifluoromethyl)aniline
4-Fluoro-3-(trifluoromethyl)aniline (CAS: 2357-47-3), with the molecular formula C7H5F4N and a molar mass of 179.11 g/mol, is a fluorinated organic building block. This compound serves as a valuable intermediate in chemical synthesis, particularly within the fields of materials science and organic chemistry. Its unique structure, featuring both a fluorine atom and a trifluoromethyl group on an aniline core, makes it suitable for creating specialised polymers and complex organic molecules.
- IUPAC
- 5-Amino-2-fluorobenzotrifluoride,α,α,α,4-Tetrafluoro-m-toluidine
- Synonyms
- 5-Amino-2-fluorobenzotrifluorideα,α,α,4-Tetrafluoro-m-toluidine
Synthesis of Fluorinated Polymers
4-Fluoro-3-(trifluoromethyl)aniline is employed in the synthesis of advanced polymers. It was specifically utilised in the creation of well-defined rod-coil block copolymers of trifluoromethylated poly(phenylene oxide), showcasing its utility in materials science.
Organic Synthesis Intermediate
As a versatile building block, this compound is instrumental in the construction of more complex organic molecules. Its reactive amine group and the presence of electron-withdrawing fluorinated substituents allow for diverse chemical transformations in multi-step syntheses.
Fluorinated Building Block
The compound's structure makes it a key component in introducing fluorinated moieties into target molecules. This is crucial for applications where enhanced thermal stability, altered electronic properties, or specific biological activity is desired.
| Molecular weight | 179.11 |
|---|---|
| Linear formula | FC6H3(CF3)NH2 |
| Assay | 99% |
| Boiling point | 207-208 °C(lit.) |
| Density | 1.393 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.466(lit.) |
| Storage temperature | 2-8°C |
| Application | 4-Fluoro-3-(trifluoromethyl)aniline was used in the synthesis of well-defined rod-coil block copolymers of trifluoromethylated poly(phenylene oxide)1. |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 92 °C / 197.6 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluoro-3-(trifluoromethyl)aniline used for?
+
4-Fluoro-3-(trifluoromethyl)aniline is primarily used as a building block in organic synthesis, including the preparation of specialised polymers such as trifluoromethylated poly(phenylene oxide) copolymers.
What are the CAS number and formula for 4-Fluoro-3-(trifluoromethyl)aniline?
+
The CAS number is 2357-47-3 and the linear formula is FC6H3(CF3)NH2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 4-Fluoro-3-(trifluoromethyl)aniline with an assay of 99%. We do not represent this product as USP, BP, or EP grade.
What are the safety and handling considerations for this chemical?
+
This compound is classified with a Warning signal word and carries hazard statements H302, H312, H315, H319, H332, and H335. It is harmful if swallowed, in contact with skin, or if inhaled, causes skin irritation, and causes serious eye irritation. Appropriate personal protective equipment, including eyeshields, face shields, gloves, and suitable respiratory protection, must be used. Store at 2-8°C.
How is 4-Fluoro-3-(trifluoromethyl)aniline packed and shipped?
+
4-Fluoro-3-(trifluoromethyl)aniline is typically shipped under conditions suitable for its stability, potentially with specific hazard classifications such as NA 1993 / PGIII. We ensure adherence to all relevant export regulations.
How can I request a sample or quote?
+
Please contact our sales department via the website or direct email to request a sample or a quotation for 4-Fluoro-3-(trifluoromethyl)aniline.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis