3-Fluoro-4-nitrotoluene
3-Fluoro-4-nitrotoluene (CAS: 446-34-4, Formula: C7H6FNO2, MW: 155.13) is a fluorinated aromatic compound supplied by Tech Serve Solutions. This chemical serves as a crucial building block in organic synthesis, particularly in the preparation of pharmaceutical intermediates. It is valued for its specific reactivity patterns conferred by the fluorine and nitro substituents, enabling complex molecular architectures.
Pharmaceutical Intermediate Synthesis
3-Fluoro-4-nitrotoluene is utilised in the synthesis of active pharmaceutical ingredients (APIs). Its structure is incorporated into molecules designed for therapeutic applications, such as the preparation of IκB kinase (IKK) inhibitors.
Organic Building Block
As a versatile organic building block, this compound is employed in various chemical synthesis pathways. The presence of both a fluorine atom and a nitro group allows for diverse functional group transformations and regioselective reactions.
Research and Development
Researchers in academic and industrial settings use 3-Fluoro-4-nitrotoluene for developing novel compounds and exploring new synthetic methodologies. Its specific electronic properties make it an interesting substrate for studying reaction mechanisms.
| Molecular weight | 155.13 |
|---|---|
| Linear formula | CH3C6H3(NO2)F |
| Assay | 99% |
| Boiling point | 97-98 °C/3 mmHg(lit.) |
| Application | 3-Fluoro-4-nitrotoluene has been used in the preparation of IκB kinase (IKK) inhibitor, BMS [N1-(1,8-dimethylimidazo[1,2-a]quinolin-4-yl)-ethane-1,2-diamine]1. |
| Melting point | 52-55 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Fluoro-4-nitrotoluene used for?
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3-Fluoro-4-nitrotoluene is primarily used as a building block in organic synthesis, particularly for preparing pharmaceutical intermediates such as IκB kinase (IKK) inhibitors.
What is the CAS number and chemical formula for 3-Fluoro-4-nitrotoluene?
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The CAS number for 3-Fluoro-4-nitrotoluene is 446-34-4, and its chemical formula is CH3C6H3(NO2)F.
What grade and purity does Tech Serve Solutions supply for 3-Fluoro-4-nitrotoluene?
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Tech Serve Solutions supplies 3-Fluoro-4-nitrotoluene with an assay of 99%. We do not represent this product as USP, BP, or EP grade.
How should 3-Fluoro-4-nitrotoluene be handled safely?
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3-Fluoro-4-nitrotoluene is harmful if swallowed, in contact with skin, or if inhaled, and causes skin and eye irritation, and may cause respiratory irritation. Appropriate personal protective equipment including a dust mask type N95 (US), eyeshields, and gloves should be used. Handle in a well-ventilated area.
Is 3-Fluoro-4-nitrotoluene a controlled substance?
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Based on the provided data, 3-Fluoro-4-nitrotoluene is not indicated as a controlled substance. However, users should always verify local regulations.
How is 3-Fluoro-4-nitrotoluene packed and shipped?
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3-Fluoro-4-nitrotoluene is carefully packed and exported according to international shipping regulations for chemical products by Tech Serve Solutions.
How can I request a sample or quote for 3-Fluoro-4-nitrotoluene?
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To request a sample or a quote for 3-Fluoro-4-nitrotoluene, please contact our sales department through the Tech Serve Solutions website.
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