3-Fluoro-4-methylphenylzinc iodide solution
3-Fluoro-4-methylphenylzinc iodide solution (CAS: 312693-08-6; Formula: FC6H3(CH3)ZnI; MW: 301.42) is a valuable organozinc halide reagent. Supplied as a 0.5 M solution in THF, it is employed in organic synthesis, particularly for cross-coupling reactions. Its reactivity makes it a useful building block for introducing the 3-fluoro-4-methylphenyl moiety into complex molecules, supporting advancements in materials science and medicinal chemistry.
Cross-Coupling Reactions
This organozinc reagent is instrumental in various palladium-catalyzed cross-coupling reactions, such as Negishi coupling. It efficiently forms new carbon-carbon bonds by reacting with aryl or vinyl halides and triflates.
Synthesis of Fluorinated Aromatics
It serves as a key intermediate for the preparation of complex fluorinated aromatic compounds. The presence of fluorine can significantly alter the electronic and lipophilic properties of molecules, which is crucial in drug discovery and materials development.
Organometallic Synthesis
As an organozinc halide, it participates in a range of organometallic transformations. Its specific structure allows for regioselective functionalization, enabling precise molecular construction.
| Molecular weight | 301.42 |
|---|---|
| Linear formula | FC6H3(CH3)ZnI |
| Boiling point | 65 °C |
| Density | 1 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-14-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Fluoro-4-methylphenylzinc iodide solution used for?
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This solution is primarily used as a reagent in organic synthesis, particularly for palladium-catalyzed cross-coupling reactions like Negishi coupling, to introduce the 3-fluoro-4-methylphenyl group into organic molecules.
What are the CAS number and chemical formula?
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The CAS number is 312693-08-6, and the chemical formula is FC6H3(CH3)ZnI.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 0.5 M solution in THF. The specific assay and purity are detailed in the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade.
How should 3-Fluoro-4-methylphenylzinc iodide solution be handled safely?
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This product is flammable (H225), causes serious eye irritation (H319), and may cause respiratory irritation (H335) and is suspected of causing cancer (H351). It may form explosive peroxides. Handle with appropriate personal protective equipment in a well-ventilated area, away from ignition sources. Refer to the Safety Data Sheet for comprehensive handling instructions.
How is this chemical packed, shipped, and exported?
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This product is packed according to stringent safety regulations for hazardous materials. It is shipped and exported globally by Tech Serve Solutions in compliance with all relevant transportation and customs requirements for UN 2924, Hazard Class 8(3), Packing Group II.
How can I request a sample or quote?
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To request a sample or a quotation for 3-Fluoro-4-methylphenylzinc iodide solution, please contact the Tech Serve Solutions sales team through our website or by calling us directly.
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