3-Chloro-4-fluorophenylmagnesium bromide solution
3-Chloro-4-fluorophenylmagnesium bromide solution (CAS 413589-34-1) is an organometallic reagent, specifically a Grignard reagent, with the empirical formula C6H3BrClFMg and a molecular weight of 233.75 g/mol. It is supplied as a 0.5 M solution in Tetrahydrofuran (THF). This compound is valuable in organic synthesis for introducing the 3-chloro-4-fluorophenyl group into various molecular structures, facilitating the construction of complex organic molecules.
Synthesis of Pharmaceutical Intermediates
This Grignard reagent serves as a key building block in the multi-step synthesis of complex active pharmaceutical ingredients (APIs). It enables the regioselective formation of carbon-carbon bonds, crucial for constructing the core structures of potential drug candidates.
Development of Agrochemicals
Utilised in the research and development of novel agrochemicals, including herbicides, insecticides, and fungicides. The introduction of the substituted phenyl ring can impart specific biological activities necessary for crop protection.
Fine Chemical Synthesis
Acts as a versatile reagent in the synthesis of various fine chemicals. Its reactivity allows for functionalisation of diverse substrates, leading to specialised compounds for research and industrial applications.
Materials Science Research
Can be employed in the synthesis of specialised organic materials where the 3-chloro-4-fluorophenyl moiety is incorporated to tune electronic or physical properties.
| Molecular weight | 233.75 |
|---|---|
| Empirical formula | C6H3BrClFMg |
| Boiling point | 65 °C |
| Density | 0.966 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-19-34-37-40 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Chloro-4-fluorophenylmagnesium bromide solution used for?
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It is primarily used as a Grignard reagent in organic synthesis to introduce the 3-chloro-4-fluorophenyl group into target molecules, particularly in the development of pharmaceutical intermediates, agrochemicals, and fine chemicals.
What is the CAS number and molecular formula?
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The CAS number is 413589-34-1 and the empirical formula is C6H3BrClFMg.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 0.5 M solution in THF. We do not claim USP, BP, or EP grades unless explicitly stated in the specifications. It is suitable for research and chemical synthesis purposes.
What are the main safety hazards associated with this product?
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This product is a highly flammable liquid and vapour (H225), causes severe skin burns and eye damage (H314), and may cause respiratory irritation (H335). It is also suspected of causing cancer (H351). It reacts violently with water and may form explosive peroxides. Handle with extreme care in a well-ventilated area, wearing appropriate protective equipment.
How is this chemical packed and shipped?
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This chemical is shipped as a UN 2924, Hazard Class 8 (3), Packing Group II, under regulations for corrosive and flammable liquids. It is typically packed in specialised containers suitable for reactive and flammable solutions, adhering to international shipping standards. TSS exports globally.
How can I request a sample or quote for 3-Chloro-4-fluorophenylmagnesium bromide solution?
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Please contact our sales team via the website or by phone to request a sample or a detailed quotation. Provide your specific requirements and shipping details for prompt service.
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