3-Chloro-4-fluorophenyl isocyanate
3-Chloro-4-fluorophenyl isocyanate (CAS: 50529-33-4, Formula: ClC6H3(F)NCO) is a valuable organic intermediate with a molecular weight of 171.56 g/mol. This fluorinated aromatic isocyanate serves as a key building block in chemical synthesis, particularly for introducing the 3-chloro-4-fluorophenyl moiety into more complex molecules. It is widely employed in the development of novel agrochemicals, pharmaceuticals, and materials science applications.
Pharmaceutical Intermediate
3-Chloro-4-fluorophenyl isocyanate is utilised in the synthesis of active pharmaceutical ingredients (APIs). Its reactive isocyanate group readily forms carbamates, ureas, and other derivatives crucial for drug discovery and development.
Agrochemical Synthesis
The compound acts as a building block for novel pesticides, herbicides, and fungicides. Incorporation of the fluorinated phenyl ring can enhance the biological activity and stability of agrochemical products.
Materials Science
It finds application in the creation of specialised polymers and advanced materials. The unique electronic and physical properties imparted by the chloro-fluoro substitution pattern are advantageous in material design.
Organic Synthesis Reagent
As a versatile organic building block, it is employed in various synthetic transformations, enabling the construction of complex organic structures for research and development purposes.
| Molecular weight | 171.56 |
|---|---|
| Linear formula | ClC6H3(F)NCO |
| Assay | 98% |
| Boiling point | 44 °C/17 mmHg(lit.) |
| Density | 1.377 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.541(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 88 °C / 190.4 °F |
| Transport (UN / ADR) | UN 2206 6.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Chloro-4-fluorophenyl isocyanate used for?
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3-Chloro-4-fluorophenyl isocyanate is primarily used as an intermediate and building block in the synthesis of pharmaceuticals, agrochemicals, and advanced materials.
What are the CAS number and formula for 3-Chloro-4-fluorophenyl isocyanate?
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The CAS number is 50529-33-4 and the molecular formula is ClC6H3(F)NCO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Chloro-4-fluorophenyl isocyanate with a minimum assay of 98%. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should 3-Chloro-4-fluorophenyl isocyanate be handled?
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Handle with appropriate personal protective equipment, including eyeshields, face shields, gloves, and a suitable respirator. Avoid inhalation of vapours and contact with skin and eyes, as it is harmful if swallowed, inhaled, or in contact with skin, and causes skin and eye irritation.
Is 3-Chloro-4-fluorophenyl isocyanate available for export?
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Yes, Tech Serve Solutions exports 3-Chloro-4-fluorophenyl isocyanate globally. Please contact us for shipping and regulatory details for your region.
How can I request a quote or sample?
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To request a quote or a sample of 3-Chloro-4-fluorophenyl isocyanate, please visit the product page on our website and utilise the 'Request a Quote' or 'Request a Sample' forms.
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