(Phenylsulfonyl)acetonitrile
(Phenylsulfonyl)acetonitrile (CAS 7605-28-9) is an organic compound with the formula C6H5SO2CH2CN and a molecular weight of 181.21 g/mol. This chemical serves as a valuable building block in organic synthesis. It is particularly noted for its utility in the preparation of various heterocyclic compounds, including pyridine, chromene, and thiophene derivatives, by leveraging the reactivity of its sulfone group. Available at 98% purity.
Synthesis of Pyridine Derivatives
(Phenylsulfonyl)acetonitrile is employed in the synthesis of substituted pyridines. The compound's structure allows for cyclisation reactions to form the pyridine ring system.
Preparation of Chromene Compounds
This nitrile is utilised in the construction of chromene scaffolds. These reactions often involve the sulfone moiety facilitating ring formation.
Thiophene Synthesis
(Phenylsulfonyl)acetonitrile can be used as a precursor in the synthesis of thiophene derivatives. The reactivity of the methylene group adjacent to both the sulfonyl and cyano groups is key to these transformations.
| Molecular weight | 181.21 |
|---|---|
| Linear formula | C6H5SO2CH2CN |
| Assay | 98% |
| Application | (Phenylsulfonyl)acetonitrile was used in the synthesis of pyridines, chromenes and thiophene derivatives based on sulfones1. |
| Melting point | 112-114 °C(lit.) |
Hazard statements
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23/24/25 |
| Safety statements (S) | 36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (Phenylsulfonyl)acetonitrile used for?
+
(Phenylsulfonyl)acetonitrile is used as a building block in organic synthesis, particularly for the preparation of pyridine, chromene, and thiophene derivatives.
What are the CAS number and formula for (Phenylsulfonyl)acetonitrile?
+
The CAS number for (Phenylsulfonyl)acetonitrile is 7605-28-9, and its chemical formula is C6H5SO2CH2CN.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies (Phenylsulfonyl)acetonitrile with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should (Phenylsulfonyl)acetonitrile be handled safely?
+
Due to its toxicity (H301, H311, H331), (Phenylsulfonyl)acetonitrile must be handled with appropriate personal protective equipment, including eyeshields, face shields, gloves, and P2 respirator cartridges. Work should be conducted in a well-ventilated area or fume hood. Always refer to the Safety Data Sheet for comprehensive handling instructions.
Is (Phenylsulfonyl)acetonitrile a controlled substance?
+
The provided data does not indicate that (Phenylsulfonyl)acetonitrile is a controlled substance.
How is (Phenylsulfonyl)acetonitrile packed and shipped?
+
Tech Serve Solutions exports chemicals globally, ensuring appropriate packaging and documentation for safe and compliant transport. Specific packaging details are confirmed upon order.
How can I request a quote or sample?
+
To request a quote or sample of (Phenylsulfonyl)acetonitrile, please contact our sales department via the website or direct inquiry channels.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis