4-Fluoro-3-methylphenyl isocyanate
4-Fluoro-3-methylphenyl isocyanate (CAS: 351003-65-1), with the molecular formula C7H3F N O, is a fluorinated aromatic isocyanate. This compound serves as a valuable building block in organic synthesis, particularly for introducing the 4-fluoro-3-methylphenyl moiety into more complex molecules. Its reactivity makes it useful in the development of pharmaceuticals, agrochemicals, and novel materials through reactions characteristic of isocyanates.
Organic Synthesis Intermediate
Utilised as a reactive intermediate in the synthesis of diverse organic compounds. The isocyanate group readily participates in addition reactions with nucleophiles like alcohols, amines, and water to form urethanes, ureas, and carbamic acids, respectively.
Pharmaceutical Research
Employed in the creation of novel pharmaceutical candidates. The presence of fluorine can influence pharmacokinetic properties such as metabolic stability and lipophilicity, making it a target for medicinal chemistry exploration.
Agrochemical Development
Serves as a precursor for the synthesis of potential agrochemicals, including herbicides, insecticides, and fungicides. Fluorinated aromatic structures are common in many modern crop protection agents.
Materials Science
Can be incorporated into polymers and advanced materials. The unique properties conferred by the fluorinated aromatic ring may lead to materials with enhanced thermal stability, chemical resistance, or specific electronic properties.
| Molecular weight | 151.14 |
|---|---|
| Linear formula | FC6H3(CH3)NCO |
| Assay | 98% |
| Boiling point | 186 °C(lit.) |
| Density | 1.172 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5120(lit.) |
| Storage temperature | 2-8°C |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 57 °C / 134.6 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluoro-3-methylphenyl isocyanate used for?
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4-Fluoro-3-methylphenyl isocyanate is primarily used as a versatile building block in organic synthesis, particularly for the preparation of pharmaceuticals, agrochemicals, and advanced materials. Its isocyanate functionality allows for straightforward derivatisation into ureas, urethanes, and other functional groups.
What are the CAS number and molecular formula for 4-Fluoro-3-methylphenyl isocyanate?
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The CAS number for 4-Fluoro-3-methylphenyl isocyanate is 351003-65-1, and its molecular formula is C7H3F N O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Fluoro-3-methylphenyl isocyanate with a minimum purity of 98%. This product is supplied for research and chemical synthesis purposes and is not represented as meeting USP, BP, EP, or any other pharmacopoeia standards.
How should 4-Fluoro-3-methylphenyl isocyanate be handled safely?
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4-Fluoro-3-methylphenyl isocyanate is a flammable liquid and vapour (H226) and is harmful if swallowed, in contact with skin, or if inhaled (H302, H312, H332). It also causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Handle in a well-ventilated area, away from ignition sources, wearing appropriate personal protective equipment including gloves, eye protection, and respiratory protection. Refer to the Safety Data Sheet for full details.
How is 4-Fluoro-3-methylphenyl isocyanate packed, shipped, and exported?
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Tech Serve Solutions professionally packs, ships, and exports chemicals globally, adhering to all relevant transport regulations. For 4-Fluoro-3-methylphenyl isocyanate, it is classified under UN 1993, Packing Group III.
How can I request a sample or a quote for 4-Fluoro-3-methylphenyl isocyanate?
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To request a sample or a quote for 4-Fluoro-3-methylphenyl isocyanate, please contact our sales team through the website or by phone, providing your specific requirements.
Does 4-Fluoro-3-methylphenyl isocyanate require special storage conditions?
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Yes, 4-Fluoro-3-methylphenyl isocyanate should be stored under refrigeration at 2-8°C due to its reactivity and potential for degradation. Ensure containers are tightly sealed to prevent moisture ingress.
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