4-Fluoro-3-methylphenylmagnesium bromide solution
4-Fluoro-3-methylphenylmagnesium bromide solution (CAS 82297-89-0) is a Grignard reagent with the molecular formula C7H7BrFMg and a molecular weight of 213.33 g/mol. Supplied as a 1.0 M solution in THF, this organometallic compound is vital in organic synthesis for introducing the 4-fluoro-3-methylphenyl moiety into various molecules. Its reactivity makes it a key intermediate in the development of pharmaceuticals and agrochemicals.
Organic Synthesis Intermediate
As a Grignard reagent, 4-Fluoro-3-methylphenylmagnesium bromide solution is extensively used in carbon-carbon bond formation reactions. It facilitates the synthesis of complex organic molecules by reacting with electrophiles like aldehydes, ketones, esters, and epoxides.
Pharmaceutical Development
This reagent serves as a crucial building block in the synthesis pathways of active pharmaceutical ingredients (APIs). Its specific fluoro-methylphenyl structure can be incorporated into drug candidates to modulate pharmacokinetic and pharmacodynamic properties.
Agrochemical Research
The 4-fluoro-3-methylphenyl group can be integrated into the molecular structures of novel pesticides, herbicides, and fungicides. This reagent provides a direct route to incorporate this functional group for exploring new agrochemical agents.
Materials Science
Organometallic reagents like this are employed in the synthesis of specialized polymers and organic electronic materials. The unique electronic properties conferred by the fluorinated aromatic ring can be advantageous in these applications.
| Molecular weight | 213.33 |
|---|---|
| Linear formula | FC6H3(CH3)MgBr |
| Density | 1.001 g/mL at 25 °C |
| Concentration | 1.0 M in THF |
Hazard statements
- H225Highly flammable liquid and vapour
- H250Catches fire spontaneously if exposed to air
- H261In contact with water releases flammable gas
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P222Do not allow contact with air
- P231Handle under inert gas
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P422
| Flash point | -26 °C / -14.8 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-17-19-34-37-40 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluoro-3-methylphenylmagnesium bromide solution used for?
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4-Fluoro-3-methylphenylmagnesium bromide solution is primarily used as a versatile Grignard reagent in organic synthesis, particularly for the formation of carbon-carbon bonds in the development of pharmaceuticals, agrochemicals, and advanced materials.
What is the CAS number and formula for 4-Fluoro-3-methylphenylmagnesium bromide solution?
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The CAS number is 82297-89-0, and the linear formula is FC6H3(CH3)MgBr. The molecular weight is 213.33 g/mol.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 1.0 M solution in THF. We do not represent this product as USP, BP, or EP grade. Please refer to the product specifications for detailed purity information.
How is 4-Fluoro-3-methylphenylmagnesium bromide solution shipped and handled?
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This is a flammable liquid and solid, corrosive, and water-reactive material. It must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent contact with air and moisture. Store in a cool, well-ventilated area away from ignition sources. Refer to the Safety Data Sheet (SDS) for comprehensive handling and storage instructions.
Is 4-Fluoro-3-methylphenylmagnesium bromide solution a controlled substance?
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The provided data does not indicate that this compound is a controlled substance.
How can I request a quote or sample for 4-Fluoro-3-methylphenylmagnesium bromide solution?
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To request a quote or a sample, please contact our sales team through the website or by calling our dedicated inquiry line. Please specify the quantity and your delivery location.
What are the primary hazards associated with this product?
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This product is a severe hazard. It is extremely flammable (flash point -26 °C), can spontaneously ignite in air, and reacts violently with water. It causes severe skin burns and eye damage and may cause respiratory irritation. There is also evidence of suspected human carcinogenicity.
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