4-Fluoro-3-nitrobenzotrifluoride
4-Fluoro-3-nitrobenzotrifluoride (CAS: 367-86-2), with the chemical formula FC6H3(NO2)CF3, is a fluorinated organic compound with a molecular weight of 209.10 g/mol. This versatile building block finds application in chemical synthesis, particularly in the creation of derivatization reagents for analytical chemistry and the synthesis of complex organic molecules. Its unique structure makes it a valuable intermediate for researchers and manufacturers.
- IUPAC
- 3-Nitro-α,α,α,4-tetrafluorotoluene,4,α,α,α-Tetrafluoro-3-nitrotoluene,FNBT
Derivatization Reagent Synthesis
Utilised in the synthesis of reagents like 2-nitro-4-trifluoromethylphenylhydrazine and [3-(2-nitro-4-trifluoromethylphenyl)aminophenyl]dihydroxyborane, which are employed for the derivatization of 1,2-diol compounds and oxo-steroids in analytical techniques.
Pre-column Derivatization in HPLC
Employed in pre-column derivatization techniques for High-Performance Liquid Chromatography (HPLC) with UV/VIS spectrophotometric detection, particularly for the analysis of polyamines.
Organic Synthesis Intermediate
Serves as a key intermediate in the synthesis of various organic compounds, including heterocyclic structures such as 1-(3-chlorophenyl)-5-trifluoromethyl-3-hydrobenzimidazol-2-one.
| Molecular weight | 209.10 |
|---|---|
| Linear formula | FC6H3(NO2)CF3 |
| Assay | 99% |
| Boiling point | 92 °C/15 mmHg(lit.) |
| Density | 1.494 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.462(lit.) |
| Application | 4-Fluoro-3-nitrobenzotrifluoride was used in pre-column derivatization technique for HPLC with UV/VIS spectrophotometric detection of polyamines1. It was also used in the synthesis of:• 2-nitro-4-trifluoromethylphenylhydrazine, derivatization reagent for 1,2-diol compounds and oxo-steroids2• [3-(2-nitro-4-trifluoromethylphenyl)aminophenyl]dihydroxyborane, derivatization reagent for 1,2-diol compounds and oxo-steroids2• 1-(3-chlorophenyl)-5-trifluoromethyl-3-hydrobenzimidazol-2-one3 |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 33 °C / 91.4 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluoro-3-nitrobenzotrifluoride used for?
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4-Fluoro-3-nitrobenzotrifluoride is used in chemical synthesis, including the preparation of derivatization reagents for analytical chemistry and as an intermediate in the synthesis of organic compounds.
What are the CAS number and formula for 4-Fluoro-3-nitrobenzotrifluoride?
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The CAS number is 367-86-2 and the linear formula is FC6H3(NO2)CF3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Fluoro-3-nitrobenzotrifluoride with a purity of 99%. This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 4-Fluoro-3-nitrobenzotrifluoride be handled safely?
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4-Fluoro-3-nitrobenzotrifluoride is a flammable liquid and vapour (H226) and can cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Ensure adequate ventilation, wear appropriate personal protective equipment including eyeshields, faceshields, gloves, and a suitable respirator. Store away from heat, sparks, open flames, and hot surfaces.
Is 4-Fluoro-3-nitrobenzotrifluoride exported by TSS?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 4-Fluoro-3-nitrobenzotrifluoride.
How can I request a quote or sample?
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Please contact our sales team via the website or by phone to request a quote or a sample of 4-Fluoro-3-nitrobenzotrifluoride.
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