4-Fluoro-3-nitrophenyl isocyanate
4-Fluoro-3-nitrophenyl isocyanate (CAS: 65303-82-4; Formula: FC6H3(NO2)NCO; Molar Mass: 182.11 g/mol) is a specialised organic compound. Possessing both an isocyanate group and a nitro-substituted fluorophenyl ring, it serves as a reactive intermediate in complex organic synthesis. Its primary utility lies in the construction of novel molecules for research and development, particularly within the fields of medicinal chemistry and materials science.
Organic Synthesis Intermediate
This compound is a valuable building block for introducing the 4-fluoro-3-nitrophenyl moiety into larger molecular structures. Its isocyanate functionality readily reacts with nucleophiles like amines, alcohols, and thiols to form urea, carbamate, and thiocarbamate linkages, respectively. These reactions are fundamental in constructing diverse organic scaffolds.
Pharmaceutical Research
In medicinal chemistry, 4-Fluoro-3-nitrophenyl isocyanate can be employed in the synthesis of potential drug candidates. The presence of fluorine and the nitro group can influence pharmacokinetic properties, such as metabolic stability and lipophilicity, making it an attractive synthon for exploring new therapeutic agents.
Materials Science
The reactivity of the isocyanate group allows for its incorporation into polymers and functional materials. Derivatives of this compound may find applications in areas requiring specific electronic or structural properties, driven by the electron-withdrawing nature of the fluoro and nitro substituents.
| Molecular weight | 182.11 |
|---|---|
| Linear formula | FC6H3(NO2)NCO |
| Assay | 98% |
| Density | 1.455 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5684(lit.) |
| Melting point | 27-28 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3335 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37 |
| Safety statements (S) | 23-26-28-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Fluoro-3-nitrophenyl isocyanate used for?
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4-Fluoro-3-nitrophenyl isocyanate is primarily used as a reactive intermediate in organic synthesis, particularly for building complex molecules in pharmaceutical research and materials science.
What are the CAS number and molecular formula?
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The CAS number for 4-Fluoro-3-nitrophenyl isocyanate is 65303-82-4, and its molecular formula is FC6H3(NO2)NCO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Fluoro-3-nitrophenyl isocyanate with a minimum assay of 98%. This product is supplied for laboratory and research purposes and is not represented as USP, BP, EP, or other pharmacopoeial grades.
How should this chemical be handled safely?
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4-Fluoro-3-nitrophenyl isocyanate is a Warning substance and is harmful if swallowed, in contact with skin, or if inhaled. It also causes serious eye irritation and may cause respiratory irritation. Always use appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, and handle in a well-ventilated area. Refer to the Safety Data Sheet for comprehensive handling guidelines.
Is this chemical a controlled substance?
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The provided data does not indicate that 4-Fluoro-3-nitrophenyl isocyanate is a controlled or scheduled substance.
How is this chemical packed, shipped, or exported?
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Tech Serve Solutions exports chemicals globally, adhering to all relevant shipping and customs regulations. Packing is done according to industry standards to ensure product integrity and safety during transit. Specific details can be provided upon request.
How can I request a sample or quote for 4-Fluoro-3-nitrophenyl isocyanate?
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To request a sample or a quotation, please contact our sales department via the website or provide your details through the 'Enquire Now' form, specifying the product CAS number 65303-82-4.
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