3,4,5-Trifluorobenzoyl chloride
3,4,5-Trifluorobenzoyl chloride (CAS: 177787-26-7) is a fluorinated aromatic acyl halide with the molecular formula C7H2ClF3O. This reactive compound serves as a versatile building block in organic synthesis, particularly for introducing the 3,4,5-trifluorobenzoyl moiety into more complex molecules. Its primary applications lie in the development of novel pharmaceuticals, agrochemicals, and advanced materials, leveraging the unique electronic properties conferred by the fluorine atoms.
- Synonyms
- 177787-26-7F3C6H2COCI
Pharmaceutical Synthesis
3,4,5-Trifluorobenzoyl chloride is employed as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its structure allows for the incorporation of fluorinated phenyl rings, which can enhance metabolic stability and binding affinity in drug candidates.
Agrochemical Development
This compound is utilised in the research and development of new pesticides and herbicides. The trifluorobenzoyl group can modify the biological activity and environmental persistence of agrochemical compounds.
Materials Science
It serves as a building block for creating specialised polymers and functional materials. The fluorine substituents can impart desirable properties such as thermal stability, chemical resistance, and altered electronic characteristics.
Organic Chemistry Research
As a reactive acylating agent, 3,4,5-Trifluorobenzoyl chloride is a valuable reagent for academic and industrial research in organic synthesis, enabling the creation of diverse fluorinated organic molecules.
| Molecular weight | 194.54 |
|---|---|
| Linear formula | F3C6H2COCI |
| Assay | 97% |
| Boiling point | 173-174 °C(lit.) |
| Density | 1.4850 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4900(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,4,5-Trifluorobenzoyl chloride used for?
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3,4,5-Trifluorobenzoyl chloride is primarily used as a building block in organic synthesis for the development of pharmaceuticals, agrochemicals, and advanced materials. It is an acylating agent that introduces the 3,4,5-trifluorobenzoyl group into molecules.
What are the CAS number and molecular formula for 3,4,5-Trifluorobenzoyl chloride?
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The CAS number for 3,4,5-Trifluorobenzoyl chloride is 177787-26-7. Its molecular formula is C7H2ClF3O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,4,5-Trifluorobenzoyl chloride with an assay of 97%. We do not represent this product as USP, BP, EP or other pharmacopoeia grades.
How should 3,4,5-Trifluorobenzoyl chloride be handled safely?
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3,4,5-Trifluorobenzoyl chloride is a corrosive substance that causes severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment including gloves, goggles, a face shield, and a suitable respirator. Ensure adequate ventilation. Refer to the Safety Data Sheet for comprehensive handling information.
How is 3,4,5-Trifluorobenzoyl chloride packed and exported?
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3,4,5-Trifluorobenzoyl chloride is packed in compliance with relevant transport regulations, including UN 3265, Class 8, Packing Group II. Tech Serve Solutions is experienced in exporting chemicals globally.
How can I request a quote or sample for 3,4,5-Trifluorobenzoyl chloride?
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To request a quote or a sample of 3,4,5-Trifluorobenzoyl chloride, please contact our sales department via the website or provide your details through the 'Enquire Now' form.
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