3,4,5-Trifluorobenzyl bromide
3,4,5-Trifluorobenzyl bromide (CAS: 220141-72-0) is a fluorinated organic building block with the molecular formula F 3 C 6 H 2 CH 2 Br and a molecular weight of 225.01 g/mol. This compound serves as a valuable intermediate in organic synthesis, particularly for introducing the 3,4,5-trifluorobenzyl moiety into more complex molecules. Its structure makes it suitable for research and development in various chemical and material science applications.
- Synonyms
- 220141-72-0F3C6H2CH2Br

Pharmaceutical Intermediate
This compound can be employed in the synthesis of novel pharmaceutical agents. The trifluorinated phenyl ring offers unique electronic and lipophilic properties beneficial for drug discovery.
Agrochemical Synthesis
It may serve as a building block for the development of new agrochemicals. Fluorinated compounds are often explored for enhanced biological activity and stability in agricultural applications.
Material Science Research
Used in research laboratories for the synthesis of advanced materials. The incorporation of fluorinated aromatic rings can modify material properties such as thermal stability and dielectric constants.
Organic Synthesis Reagent
As a benzyl bromide derivative, it functions as an alkylating agent in diverse organic transformations. It is useful for introducing the 3,4,5-trifluorobenzyl group into various organic frameworks.
| Molecular weight | 225.01 |
|---|---|
| Linear formula | F3C6H2CH2Br |
| Assay | 95% |
| Density | 1.689 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5050(lit.) |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 65 °C / 149 °F |
| Transport (UN / ADR) | UN 1760 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,4,5-Trifluorobenzyl bromide used for?
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3,4,5-Trifluorobenzyl bromide is primarily used as a building block and intermediate in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and advanced materials.
What is the CAS number and formula for 3,4,5-Trifluorobenzyl bromide?
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The CAS number for 3,4,5-Trifluorobenzyl bromide is 220141-72-0, and its linear formula is F 3 C 6 H 2 CH 2 Br.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,4,5-Trifluorobenzyl bromide with a minimum assay of 95%. TSS does not represent this product as USP, BP, EP, or any pharmacopoeia grade.
How should 3,4,5-Trifluorobenzyl bromide be handled safely?
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3,4,5-Trifluorobenzyl bromide is classified as Danger with hazard statement H314 (Causes severe skin burns and eye damage). Appropriate personal protective equipment, including face shields, goggles, gloves, and suitable respiratory protection, must be used. Handle in a well-ventilated area and avoid contact with skin, eyes, and clothing.
Is this product suitable for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents, including 3,4,5-Trifluorobenzyl bromide.
How can I request a sample or quote for 3,4,5-Trifluorobenzyl bromide?
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To request a sample or quote, please use the contact form on our website or contact our sales department directly with your requirements.
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