3,4,5-Trifluorophenylboronic acid
3,4,5-Trifluorophenylboronic acid (CAS: 143418-49-9) is a key organometallic reagent with the molecular formula F 3 C 6 H 2 B(OH) 2 and a molecular weight of 175.90 g/mol. This compound is extensively utilised as a versatile building block in organic synthesis, particularly in Suzuki cross-coupling reactions and the preparation of complex fluorinated aromatic compounds. Its applications span pharmaceutical research and materials science.
- IUPAC
- 3,4,5-Trifluorobenzeneboronic acid
- Synonyms
- 143418-49-9F3C6H2B(OH)23,4,5-Trifluorobenzeneboronic acid
Suzuki Cross-Coupling Reactions
3,4,5-Trifluorophenylboronic acid serves as a critical coupling partner in palladium-catalysed Suzuki reactions for forming carbon-carbon bonds. This is widely employed in the synthesis of complex organic molecules, including pharmaceuticals and advanced materials.
Synthesis of Fluorinated Aromatic Compounds
The compound is instrumental in the preparation of fluorinated aromatic poly(ether-amide)s and other advanced materials. The incorporation of fluorine atoms can impart unique properties such as increased thermal stability and altered electronic characteristics.
Preparation of Phenylboronic Catechol Esters
It is used in the preparation of phenylboronic catechol esters, which are further studied for their Lewis acidity. This research contributes to understanding reaction mechanisms and developing new catalytic systems.
Development of Benzopyranone Derivatives
3,4,5-Trifluorophenylboronic acid is involved in the synthesis of specific benzopyranone derivatives. These derivatives are explored for their potential as GABAA receptor modulators, indicating its relevance in medicinal chemistry research.
| Molecular weight | 175.90 |
|---|---|
| Linear formula | F3C6H2B(OH)2 |
| Application | Reactant involved in:• Preparation of phenylboronic catechol esters and determination of Lewis acidity1• Synthesis of benzopyranone derivatives as GABAA receptor modulators2• Synthesis of multisubstituted olefins and conjugate dienes3• Suzuki cross-coupling reactions4,5• Preparation of fluorinated aromatic poly(ether-amide)s6 |
| Melting point | 290-295 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What are the primary uses of 3,4,5-Trifluorophenylboronic acid?
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This compound is primarily used as a reactant in organic synthesis, including Suzuki cross-coupling reactions, the preparation of fluorinated aromatic poly(ether-amide)s, synthesis of benzopyranone derivatives, and preparation of phenylboronic catechol esters.
What is the CAS number and molecular formula for 3,4,5-Trifluorophenylboronic acid?
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The CAS number is 143418-49-9, and the molecular formula is F 3 C 6 H 2 B(OH) 2 .
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,4,5-Trifluorophenylboronic acid for research and chemical synthesis purposes. The specific assay and purity are detailed in the product specifications. We do not represent this product as USP, BP, EP, or other pharmacopoeial grades unless explicitly stated.
How should 3,4,5-Trifluorophenylboronic acid be handled?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter should be used. Refer to the Safety Data Sheet for comprehensive handling and hazard information.
Is 3,4,5-Trifluorophenylboronic acid a controlled substance?
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The provided data does not indicate that 3,4,5-Trifluorophenylboronic acid is a controlled substance.
How can I request a quote or sample for 3,4,5-Trifluorophenylboronic acid?
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To request a quote or sample, please contact our sales team through the details provided on the Tech Serve Solutions website.
How is 3,4,5-Trifluorophenylboronic acid typically exported?
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Tech Serve Solutions is a global supplier and exporter. 3,4,5-Trifluorophenylboronic acid is carefully packaged and exported in compliance with international shipping regulations for chemical substances.
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