1(S),9(R)-(−)-Bicuculline methbromide

CAS 66016-70-4C21H20BrNO6Cell Biology

1(S),9(R)-(−)-Bicuculline methbromide (CAS: 66016-70-4) is a white to off-white solid with a molecular weight of 462.29 g/mol. As a GABAergic antagonist, this compound is primarily utilised in neuroscience research to investigate the role of GABA receptors in various physiological and pathological processes. Its specific stereochemistry makes it a valuable tool for studying receptor subtypes and their associated signalling pathways.

IUPAC: (5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide (1:1)
Synonyms: C21H20BrNO6(5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide (1:1)

Email us

1(S),9(R)-(−)-Bicuculline methbromide (C21H20BrNO6) — chemical structure, CAS 66016-70-4; Life Science, fine chemical supplied by Tech Serve Solutions

AntagonistsBioactive Small MoleculesCell BiologyGABAergicsNeuroscienceNeurotransmissionNeurotransmitters More...

01 /Applications

Neuroscience Research

Used as a selective antagonist of GABA-A receptors to study neuronal excitability and synaptic transmission in various brain regions.

Pharmacological Tool

Employed in preclinical studies to probe the effects of GABAergic system modulation on behaviour and neurological function.

Cell Signaling Studies

Investigates the downstream effects of GABA receptor blockade on intracellular signalling cascades within neuronal cells.

02 /Properties

Molecular weight	462.29
Empirical formula	C21H20BrNO6
Assay	≥98% (HPLC)
Form	solid
Colour	white to off-white
Solubility	H2O: >10 mg/mL
Storage temperature	2-8°C

03 /Safety & handling

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P264Wash thoroughly after handling
P273Avoid release to the environment
P280Wear protective gloves, clothing and eye/face protection
P301IF SWALLOWED
P311Call a POISON CENTER or doctor

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Transport (UN / ADR)	UN 1544 6.1/PG 3
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

66016-70-4

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 1(S),9(R)-(−)-Bicuculline methbromide used for?

1(S),9(R)-(−)-Bicuculline methbromide is primarily used as a research tool in neuroscience to antagonise GABA-A receptors, helping to study neuronal excitability and neurotransmission.

What is the CAS number and formula for 1(S),9(R)-(−)-Bicuculline methbromide?

The CAS number is 66016-70-4, and the empirical formula is C21H20BrNO6.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 1(S),9(R)-(−)-Bicuculline methbromide with a purity of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.

How should 1(S),9(R)-(−)-Bicuculline methbromide be handled safely?

Handle with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Refer to the safety data sheet for detailed handling instructions.

Is this chemical a controlled substance?

This information is not available in the provided data. Please consult relevant national and international regulations regarding controlled substances.

How is 1(S),9(R)-(−)-Bicuculline methbromide packed and shipped?

This compound is shipped as a solid and is classified under UN 1544, Hazard Class 6.1, Packing Group 3. Please contact us for specific packaging and shipping details.