1(S),9(R)-(−)-Bicuculline methiodide

CAS 40709-69-1C21H20INO6Cell Biology

1(S),9(R)-(−)-Bicuculline methiodide (CAS 40709-69-1) is a high-purity chemical compound with a molecular weight of 509.29 g/mol. It is known for its activity as a GABA-A receptor antagonist. This compound finds primary application in neuroscientific research, particularly in studying neuronal excitability and synaptic transmission. Its specific stereochemistry and inhibitory properties make it a valuable tool in understanding complex brain functions.

IUPAC: (5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
Synonyms: C21H20INO6(5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide

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1(S),9(R)-(−)-Bicuculline methiodide (C21H20INO6) — chemical structure, CAS 40709-69-1; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesCell Biology

01 /Applications

Neuroscience Research Tool

Utilised as a selective antagonist of GABA-A receptors to investigate neuronal excitability and synaptic plasticity in various research models.

Pharmacological Studies

Employed in in vitro and in vivo studies to elucidate the role of GABAergic pathways in physiological and pathological conditions.

Cell Biology Investigations

Applied in cell culture experiments to modulate neuronal activity and study cellular responses to GABA receptor blockade.

02 /Properties

Molecular weight	509.29
Empirical formula	C21H20INO6
Assay	≥95.0% (HPCE)
Solubility	H2O: soluble10 mg/mL, almost clear, greenish-yellow
Optical activity	[α]/D -116±6°, c = 1 in chloroform
Storage temperature	2-8°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

40709-69-1

Beilstein registry

5419649

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 1(S),9(R)-(−)-Bicuculline methiodide used for?

This compound is primarily used as a GABA-A receptor antagonist in neuroscience research to study neuronal excitability and synaptic transmission.

What is the CAS number and formula for 1(S),9(R)-(−)-Bicuculline methiodide?

The CAS number is 40709-69-1 and its empirical formula is C21H20INO6.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 1(S),9(R)-(−)-Bicuculline methiodide with a minimum assay of 95.0% determined by HPCE. TSS does not represent this product as USP, EP, or BP grade.

How should 1(S),9(R)-(−)-Bicuculline methiodide be handled?

Handle with appropriate personal protective equipment, including eyeshields and gloves. Use a type N95 (US) or type P1 (EN143) respirator filter. This compound has a WGK of 3 in Germany, indicating significant hazard.